Description

2,4-Difluorobenzenethiol is a versatile organosulfur building block characterized by its reactive thiol group and fluorine substituents. This compound matters for its role as a critical intermediate in the synthesis of complex molecules, particularly in the pharmaceutical and agrochemical sectors. Industries requiring advanced chemical synthesis, such as pharmaceutical R&D, agrochemical manufacturing, and materials science, need this high-purity reagent for constructing novel compounds with specific biological or physical properties.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing active pharmaceutical ingredients (APIs), especially those containing sulfur and fluorine motifs for enhanced metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the difluorophenylthiol moiety contributes to efficacy and selectivity.
• Ligand and Catalyst Preparation: Serves as a precursor for creating specialized ligands in transition metal catalysis and organocatalysis.
• Material Science: Employed in the development of novel polymers, liquid crystals, and organic electronic materials due to its ability to modify surface properties and electronic characteristics.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry in exploring new synthetic routes and molecular entities.
• Flavor and Fragrance Industry: Potential intermediate for synthesizing specific sulfur-containing aromatic compounds, though typically in high-purity grades.

Basic Information

Item	Detail
Product Name	2,4-Difluorobenzenethiol
CAS No.	1996-44-7
Molecular Formula	C6H4F2S
Molecular Weight	146.16 g/mol
Synonyms	2,4-Difluorothiophenol; 2,4-Difluorophenyl mercaptan; 1,3-Difluoro-4-mercaptobenzene; Benzenethiol, 2,4-difluoro-; 2,4-DFBT; (2,4-Difluorophenyl)thiol; 2,4-Difluorobenzenethiol; 2,4-Difluorophenylthiol
EINECS	Contact for details

Quality Control

Our 2,4-Difluorobenzenethiol is produced under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes rigorous analytical testing, including chromatography (GC/HPLC) and spectroscopic methods (NMR, IR), to confirm identity and quantify purity and impurity profiles. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all relevant specifications. Our quality commitment aligns with cGMP principles where applicable, supporting its use in regulated synthesis pathways.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, well-ventilated place at a controlled room temperature (15-25°C). Due to its highly volatile and light-sensitive nature, containers should be kept tightly sealed when not in use to prevent evaporation and potential degradation. Keep away from strong oxidizing agents, strong bases, and sources of ignition.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.