Description

(S)-1,2,3,4-Tetrahydroisoquinoline-3-Methanol CAS NO 1881-17-0 is a high-purity chiral building block and intermediate of significant importance in asymmetric synthesis. Its value lies in its stereochemically defined structure, which is crucial for imparting specific biological activity in final active pharmaceutical ingredients (APIs). This compound is essential for research and production in the pharmaceutical industry, particularly for the development of central nervous system (CNS) agents, cardiovascular drugs, and other therapeutic compounds requiring precise chirality.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the synthesis of potent APIs, including alkaloid derivatives and enzyme inhibitors.
• Asymmetric Catalyst Ligand Precursor: Used to develop and synthesize novel chiral ligands for catalytic asymmetric reactions.
• Neurological Research: Serves as a core scaffold in medicinal chemistry for developing compounds targeting neurotransmitter receptors.
• Process Chemistry & Scale-up: Employed in route development and optimization for the commercial manufacturing of chiral drugs.
• Academic & R&D Laboratories: A valuable reagent for exploring new synthetic methodologies and creating compound libraries for biological screening.
• Fine Chemical Synthesis: Used in the production of other complex, high-value specialty chemicals requiring the tetrahydroisoquinoline moiety.

Basic Information

Product Name	(S)-1,2,3,4-Tetrahydroisoquinoline-3-Methanol
CAS No.	1881-17-0
Molecular Formula	C10H13NO
Molecular Weight	163.22 g/mol
Synonyms	(S)-1,2,3,4-Tetrahydro-3-isoquinolinemethanol; (S)-TIHM; (3S)-1,2,3,4-Tetrahydroisoquinoline-3-methanol; (S)-(-)-1,2,3,4-Tetrahydroisoquinoline-3-methanol; (S)-THIQ-3-Methanol; L-1,2,3,4-Tetrahydroisoquinoline-3-carbinol; (S)-1,2,3,4-Tetrahydro-3-isoquinolinecarbinol
EINECS	Contact for details

Quality Control

Our (S)-1,2,3,4-Tetrahydroisoquinoline-3-Methanol is produced under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity analysis by HPLC, to ensure it meets the high standards required for pharmaceutical development. A detailed Certificate of Analysis (COA) providing specifications for identity, assay, chiral purity, and impurities is supplied with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% ee
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.