Description

Methyl-D3-Triphenylphosphonium Bromide is a deuterium-labeled isotopologue of the classic Wittig reagent, methyltriphenylphosphonium bromide. This compound is a critical reagent for the synthesis of isotopically labeled alkenes via the Wittig reaction, enabling the precise incorporation of deuterium atoms into target molecules. It is essential for researchers and manufacturers in pharmaceutical development, agrochemical research, and advanced material science who require stable isotope labeling for metabolic studies, tracer analysis, and mechanistic investigations.

Application

• Deuterium-Labeled Synthesis: Key reagent for the Wittig olefination reaction to introduce CD3-containing alkenes into complex molecules.
• Pharmaceutical Research: Synthesis of deuterated drug candidates and active pharmaceutical ingredients (APIs) for improved metabolic stability and pharmacokinetic studies.
• Metabolic Tracers: Production of internal standards and labeled compounds for use in mass spectrometry (LC-MS, GC-MS) for quantitative bioanalysis.
• Mechanistic Studies: Tool in organic chemistry research to investigate reaction mechanisms using kinetic isotope effects (KIE).
• Agrochemical Development: Creation of isotopically labeled pesticides and herbicides for environmental fate and metabolism studies.
• Advanced Materials: Precursor for synthesizing deuterated polymers or organic electronic materials with modified properties.

Basic Information

Product Name	Methyl-D3-Triphenylphosphonium Bromide
CAS No.	1787-44-6
Molecular Formula	C19H16D3BrP
Molecular Weight	357.24 g/mol
Synonyms	Methyl-d3-triphenylphosphonium bromide; (Methyl-d3)triphenylphosphonium bromide; (CD3)PPh3Br; Triphenyl(methyl-d3)phosphonium bromide; Phosphonium, (methyl-d3)triphenyl-, bromide; Deuterated methyltriphenylphosphonium bromide; Wittig reagent-d3
EINECS	217-242-8

Quality Control

Our Methyl-D3-Triphenylphosphonium Bromide is manufactured under strict quality protocols to ensure high isotopic purity and chemical integrity, suitable for sensitive research applications. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing key parameters such as isotopic enrichment (D-atom %), chemical purity, and identity confirmation. We adhere to cGMP principles for laboratory chemicals to ensure batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment or under inert atmosphere to prevent degradation. Keep the container tightly sealed when not in use.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Isotopic Purity (D-atom %)	≥ 98.0% (by 1H NMR or MS)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.