Description

9-Hydroxy-4-Methoxy-Psoralen is a naturally occurring furanocoumarin derivative, recognized for its significant photobiological activity. This compound is a key intermediate and active principle in the development of therapeutic agents and research tools, particularly in photochemotherapy. It is essential for manufacturers and research institutions in the pharmaceutical, cosmetic, and life science sectors seeking high-purity bioactive molecules for advanced applications.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of psoralen-based drugs used in PUVA (Psoralen + UVA) therapy for skin conditions like psoriasis and vitiligo.
• Photochemotherapy Research: Used as a standard compound in laboratory studies investigating mechanisms of photosensitization, DNA intercalation, and UVA-induced biological effects.
• Cosmetic Ingredient R&D: Investigated for potential use in controlled formulations for skin treatments, leveraging its interaction with ultraviolet light.
• Biochemical Probe: Serves as a tool in molecular biology to study cell cycle arrest, apoptosis, and other photodynamic processes in vitro.
• Analytical Reference Standard: Employed as a high-purity calibrant in HPLC, LC-MS, and other analytical methods for quality control of herbal extracts and pharmaceutical products.
• Natural Product Isolation & Synthesis: A target molecule for extraction from natural sources like figs and celery, and for total synthesis projects in organic chemistry.

Basic Information

Product Name	9-Hydroxy-4-Methoxy-Psoralen
CAS No.	1603-47-0
Molecular Formula	C₁₂H₈O₅
Molecular Weight	232.19 g/mol
Synonyms	9-Hydroxy-4-methoxyfuro[3,2-g]chromen-7-one; 4-Methoxy-9-psoralenol; 9-Hydroxy-4-methoxy-7H-furo[3,2-g][1]benzopyran-7-one; 9-Hydroxymethoxsalen; Isopimpinellin; 5-Methoxyangelicin; Contact for additional synonyms.
EINECS	Contact for details

Quality Control

We supply 9-Hydroxy-4-Methoxy-Psoralen in high-purity grades suitable for research and industrial use. Our quality assurance process includes rigorous analytical testing to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing specifications such as assay, related substances, and residual solvents is provided with each batch. We adhere to cGMP principles in our manufacturing controls to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is light-sensitive and should be handled under appropriate conditions to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.