Description

Methyltriphenylphosphonium Iodide, [Methyl-14C] is a carbon-14 labeled phosphonium salt, a crucial reagent for introducing a radiolabeled methyl group into target molecules. This compound is essential for researchers requiring precise metabolic and pharmacokinetic tracing studies. It is primarily utilized by pharmaceutical R&D teams, agrochemical scientists, and academic institutions engaged in advanced organic synthesis and radiotracer development.

Application

• Radiolabeled Synthesis: Key reagent for the preparation of carbon-14 labeled compounds via Wittig and related reactions for use in Absorption, Distribution, Metabolism, and Excretion (ADME) studies.
• Pharmaceutical Research: Enables the synthesis of radiolabeled drug candidates to track their biological fate, metabolism, and degradation pathways in vivo and in vitro.
• Agrochemical Development: Used to create labeled pesticides and herbicides to study environmental fate, soil metabolism, and plant uptake.
• Mechanistic Studies: Facilitates the elucidation of reaction mechanisms in organic chemistry by tracing the methyl group transfer.
• Metabolic Pathway Analysis: Serves as a building block for synthesizing probes used to map specific biochemical pathways in biological systems.
• Quality Control & Reference Standards: Can be used in the preparation of internal standards for analytical methods like LC-MS in regulated bioanalysis.

Basic Information

Product Name	Methyltriphenylphosphonium Iodide, [Methyl-14C]
CAS No.	1560-52-7
Molecular Formula	C20H18IP* (*14C labeled)
Molecular Weight	~416.24 g/mol (unlabeled)
Synonyms	Methyltriphenylphosphonium Iodide-14C; [14C]Methyltriphenylphosphonium Iodide; (Methyl-14C)triphenylphosphonium Iodide; Phosphonium, methyltriphenyl-, iodide, (14C)methyl-; Triphenyl(14C)methylphosphonium Iodide; MTPP-I-14C; Radiolabeled MTPP Iodide
EINECS	Contact for details

Quality Control

Every batch of Methyltriphenylphosphonium Iodide, [Methyl-14C] is manufactured and analyzed under strict quality systems to ensure high chemical and radiochemical purity, specific activity, and stability. Our quality commitment includes comprehensive analytical testing via HPLC, NMR, and radiometric detection. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting purity, specific activity (mCi/mmol or GBq/mmol), and solvent content.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere when possible to maintain stability and specific activity. For long-term storage, keep desiccated at the recommended temperature.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (NMR/HPLC)	Conforms to structure
Chemical Purity (HPLC)	≥ 98.0%
Radiochemical Purity (HPLC)	≥ 97.0%
Specific Activity	50-60 mCi/mmol (Contact for specific value)
Solvent Content (Residual Solvents)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.