Description

1-Bromo-2,3,5,6-tetrafluorobenzene is a high-purity, multi-fluorinated aromatic building block essential for advanced chemical synthesis. This compound is valued for its unique combination of bromine and fluorine substituents, which impart significant electronic and steric properties, making it a critical intermediate in the development of complex molecules. It is primarily sought by R&D chemists and process engineers in the pharmaceutical, agrochemical, and specialty materials sectors for constructing active ingredients and functional polymers.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing fluorinated aromatic motifs that can enhance metabolic stability and bioavailability.
• Agrochemical Synthesis: Used in the production of advanced herbicides, fungicides, and pesticides where the fluorine atoms improve lipophilicity and environmental persistence.
• Liquid Crystal & OLED Materials: Serves as a precursor in the manufacture of fluorinated liquid crystals and organic light-emitting diode (OLED) materials, contributing to improved electronic properties and device performance.
• Polymer & Resin Modification: Employed to introduce fluorine and bromine functional groups into polymers, enhancing properties like chemical resistance, thermal stability, and flame retardancy.
• Cross-Coupling Reactions: Acts as a versatile substrate in palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) for creating complex biaryl structures.
• Chemical Research & Development: A valuable reagent in academic and industrial R&D for exploring new synthetic methodologies and creating novel fluorinated compounds.

Basic Information

Product Name	1-Bromo-2,3,5,6-Tetrafluorobenzene
CAS No.	1559-88-2
Molecular Formula	C6HBrF4
Molecular Weight	244.97 g/mol
Synonyms	2,3,5,6-Tetrafluorobromobenzene; Benzene, 1-bromo-2,3,5,6-tetrafluoro-; 2,3,5,6-Tetrafluoro-1-bromobenzene; 1-Bromo-2,3,5,6-tetrafluorobenzol; BTFB; Bromotetrafluorobenzene
EINECS	Contact for details

Quality Control

Every batch of our 1-Bromo-2,3,5,6-tetrafluorobenzene undergoes rigorous analytical testing to ensure it meets the high standards required for sensitive synthetic applications. We employ advanced techniques including GC, HPLC, and NMR to verify identity, purity, and impurity profiles. A comprehensive Certificate of Analysis (COA) detailing all test results is provided with each shipment to guarantee traceability and batch-to-batch consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area away from incompatible materials such as strong acids and organic solvents. Recommended storage temperature is between 15°C and 25°C. Keep container tightly sealed when not in use to prevent moisture absorption and volatilization.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 98.0%
Water Content (KF)	≤ 0.1%
Density (at 20°C)	~1.9 g/mL
Boiling Point	~155-160 °C

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.