Description

L-α-(3-Thienyl)Glycine is a non-proteinogenic amino acid derivative featuring a thiophene ring, serving as a key chiral building block in advanced organic synthesis. Its primary value lies in its role as a crucial intermediate for the development of novel pharmaceuticals and bioactive compounds, particularly in peptidomimetics and enzyme inhibitors. This high-purity compound is essential for research and production in the pharmaceutical, biotechnology, and fine chemical industries, where precise stereochemistry and molecular structure are critical for activity.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the synthesis of novel drug candidates, particularly in central nervous system (CNS) and metabolic disorder research.
• Peptidomimetics Development: Used to incorporate the thienyl moiety into peptide backbones to enhance metabolic stability, bioavailability, and receptor binding affinity.
• Protease & Enzyme Inhibitor Synthesis: Serves as a key component in designing inhibitors for various enzymes, leveraging its unique structure for targeted interaction.
• Chemical Biology & Proteomics Research: Employed as a building block for creating labeled probes, affinity tags, or unnatural amino acids for studying protein function and interactions.
• Fine Chemical Synthesis: Utilized in asymmetric synthesis and catalysis for constructing complex molecules with high enantiomeric purity.
• Agrochemical Research: Acts as an intermediate in the development of new active ingredients with potential herbicidal or insecticidal properties.

Basic Information

Item	Details
Product Name	L-α-(3-Thienyl)Glycine
CAS No.	1194-87-2
Molecular Formula	C6H7NO2S
Molecular Weight	157.19 g/mol
Synonyms	(S)-2-Amino-2-(thiophen-3-yl)acetic acid; L-3-Thienylglycine; (S)-2-(3-Thienyl)glycine; (S)-α-Amino-3-thiopheneacetic acid; H-3-Thg-OH; L-α-(3-Thienyl)glycine; (S)-2-Amino-2-(3-thienyl)ethanoic acid; NSC 163063
EINECS	214-794-7

Quality Control

Our L-α-(3-Thienyl)Glycine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity verification by HPLC, to ensure it meets the high standards required for pharmaceutical research and development. A Certificate of Analysis (COA) detailing purity, enantiomeric excess, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). The product is hygroscopic (moisture-sensitive) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0% ee
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals (as Pb)	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.