Description

5-[(3S)-Dithiolan-3-Yl]Pentanoic Acid is a chiral, sulfur-containing carboxylic acid derivative, also known as (R)-α-Lipoic Acid, a vital cofactor in mitochondrial energy metabolism. This high-purity intermediate is critical for the synthesis of pharmaceutical-grade active ingredients and advanced nutritional supplements. It is essential for manufacturers in the pharmaceutical, nutraceutical, and fine chemical sectors requiring a reliable source of a key chiral building block for metabolic and antioxidant applications.

Application

• Pharmaceutical Active Ingredient (API) Synthesis: As a direct precursor for the production of (R)-α-Lipoic Acid, a potent antioxidant used in therapeutic formulations for diabetic neuropathy and liver health.
• Nutraceutical & Dietary Supplement Manufacturing: Serves as the key chiral intermediate for high-purity, bioavailable R-Lipoic Acid supplements.
• Biochemical Research & Development: Used as a standard or reagent in studies of mitochondrial function, oxidative stress, and energy metabolism pathways.
• Fine Chemical Intermediate: Employed in asymmetric synthesis and the production of other chiral molecules due to its defined stereochemistry and dithiolane functionality.
• Cosmeceutical Ingredients: Potential use in the synthesis of advanced skincare actives targeting cellular antioxidant defense and anti-aging.

Basic Information

Product Name	5-[(3S)-Dithiolan-3-Yl]Pentanoic Acid
CAS No.	1077-27-6
Molecular Formula	C8H14O2S2
Molecular Weight	206.33 g/mol
Synonyms	(R)-α-Lipoic Acid; (R)-(+)-α-Lipoic Acid; (R)-Thioctic Acid; (R)-1,2-Dithiolane-3-pentanoic Acid; (R)-5-(1,2-Dithiolan-3-yl)pentanoic Acid; (3R)-1,2-Dithiolane-3-valeric Acid; (R)-6,8-Thioctic Acid; R-ALA
EINECS	214-071-2

Quality Control

Our 5-[(3S)-Dithiolan-3-Yl]Pentanoic Acid is manufactured under strict quality systems. Each batch is tested to ensure high chemical and chiral purity, meeting the stringent requirements for pharmaceutical and nutraceutical applications. Certificates of Analysis (COA) documenting identity, purity, enantiomeric excess, and related substances are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere for long-term storage to prevent oxidation.

Specification

Item	Specification
Appearance	Yellow to light yellow crystalline powder
Identification (IR)	Conforms to reference standard
Assay (HPLC)	≥ 98.0%
Enantiomeric Purity (Chiral HPLC)	≥ 99.0% (R-isomer)
Melting Point	45 - 48 °C
Specific Rotation [α]20/D	+104° to +112° (c=1, benzene)
Heavy Metals	≤ 10 ppm
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.