Description

Triethylamine Trihydrofluoride is a versatile and highly reactive fluoride source and deprotection reagent. This compound is critical for applications requiring controlled fluorination or the selective cleavage of silicon-oxygen bonds in complex synthetic pathways. It is an essential material for research and production in the pharmaceutical, agrochemical, and advanced materials sectors, where precision and reagent purity are paramount.

Application

• Peptide Synthesis: As a key reagent for the deprotection of tert-butyloxycarbonyl (Boc) and other acid-labile protecting groups.
• Nucleic Acid Chemistry: Used in oligonucleotide synthesis for the removal of silyl protecting groups from the sugar moiety.
• Organic Synthesis: Serves as a source of fluoride ion for nucleophilic substitution reactions and the promotion of various silicon-based transformations.
• Polymer & Material Science: Employed in the surface modification of silicon-based materials and in the synthesis of fluorinated polymers.
• Agrochemical Manufacturing: Utilized as an intermediate in the synthesis of certain fluorinated active ingredients.
• Catalysis: Acts as a component or precursor in catalyst systems for specific organic reactions.

Basic Information

Product Name	Triethylamine Trihydrofluoride
CAS No.	73602-61-6
Molecular Formula	C6H15N·3HF or (C2H5)3N·3HF
Molecular Weight	161.20 g/mol
Synonyms	Triethylamine Tris(hydrofluoride); TEA·3HF; Triethylammonium Trihydrofluoride; Et3N·3HF; Triethylamine-Hydrogen Fluoride Complex (1:3); Fluorinating Agent TEA-3HF; Triethylamine Trihydrogendifluoride
EINECS	Contact for details

Quality Control

Our Triethylamine Trihydrofluoride is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing to ensure high purity and consistency, meeting the stringent requirements of fine chemical and pharmaceutical applications. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting key parameters such as assay, water content, and impurity profiles.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under anhydrous conditions to prevent decomposition. Keep away from strong acids and bases.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms
Assay (Titration)	≥ 98.0 %
Water Content (KF)	≤ 1.0 %
Free Amine Content	≤ 2.0 %

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.