Peripheral Vasodilators
Circulatory System Drugs
- Lipid Regulators
- Antianginals
- Calcium Channel Blockers
- Anticongestive Heart Failure Drugs
- Antihypertensives
- Antiarrhythmics
- Shock Vasoactive Drugs
- Other Cardiovascular Drugs
- ACE Inhibitors and ARBs
- Peripheral Vasodilators
- β-Adrenergic Receptor Blockers
- Chronic Heart Failure Therapeutics
- Antiatherosclerotic Drugs
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Peripheral Vasodilators
Peripheral vasodilators act primarily on systemic arteries or veins to reduce peripheral resistance, improve blood flow, and relieve vascular spasm. These medications include nitrates, hydralazine, minoxidil, α-blockers, and phosphodiesterase inhibitors. Their mechanisms involve smooth muscle relaxation through nitric oxide modulation, potassium channel activation, α-adrenergic blockade, or cyclic nucleotide elevation. They are used in hypertension, Raynaud’s phenomenon, peripheral vascular disease, and chronic heart failure as adjunctive therapy. Peripheral vasodilators may improve tissue perfusion, reduce afterload, and alleviate ischemic discomfort. Adverse effects such as reflex tachycardia, edema, flushing, or hypotension require careful dose titration. Despite these risks, vasodilators remain essential in managing disorders involving impaired vascular tone.
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