Polypeptides

Polypeptide antibiotics are APIs composed of cyclic or linear peptide structures that disrupt bacterial cell membranes, leading to rapid bactericidal effects. Key members include polymyxins (colistin), bacitracin, and tyrothricin. They are active primarily against multidrug-resistant Gram-negative organisms by binding to lipopolysaccharides and altering membrane permeability. Due to nephrotoxicity and neurotoxicity concerns, systemic use is limited to severe infections such as carbapenem-resistant Acinetobacter or Pseudomonas. Topical and ophthalmic formulations are widely used for skin and eye infections. Polypeptides have regained importance in the era of antimicrobial resistance as last-resort therapies.

1-[(2S)-2-[(6-Methyl-1-oxoheptyl)amino]-4-[(sulfomethyl)amino]butanoic acid]-3-[(2S)-2-amino-4-[(sulfomethyl)amino]butanoic acid]-5-[(2S)-2-amino-4-[(sulfomethyl)amino]butanoic acid]-9-[(2S)-2-amino-4-[(sulfomethyl)amino]butanoic acid]polymyxin E2 CAS NO 30387-41-8

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CAS No.:30387-41-8

Grade:Pharmacy Grade

Content:99.90%

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Malonyl Gramicidin CAS NO 9066-61-9

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CAS No.:9066-61-9

Grade:Pharmacy Grade

Content:99.90%

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Aprotinin CAS NO 9087-70-1

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CAS No.:9087-70-1

Grade:Pharmacy Grade

Content:99.90%

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