Aminoglycosides
Aminoglycosides
Aminoglycosides are broad-spectrum bactericidal APIs that inhibit bacterial protein synthesis by binding to the 30S ribosomal subunit, causing misreading of mRNA and blocking peptide elongation. Common agents include gentamicin, amikacin, tobramycin, and streptomycin. They are especially effective against aerobic Gram-negative bacteria and are widely used in sepsis, pneumonia, complicated urinary infections, and tuberculosis regimens. Aminoglycosides exhibit concentration-dependent killing and strong post-antibiotic effects. However, nephrotoxicity and ototoxicity require therapeutic drug monitoring. Their formulations include injectables, inhalation solutions, and topical preparations for ophthalmic and dermatologic infections. Aminoglycosides remain essential in severe infections despite safety considerations.
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