Description

Acetic acid, 2,2-(1S,3S,7R,8E,11S,12S,15S,17R,21R,23R,25S)-12,25-bis(acetyloxy)-1,11,21-trihydroxy-17-(1R)-1-hydroxyethyl-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo21.3.1.13,7.111,15nonacos-8-ene-5,13-diylidenebis-, dimethyl ester, (25Z) is a complex, high-purity macrolide derivative with significant biological activity. This compound is valued for its role as a critical advanced pharmaceutical intermediate in the synthesis of novel therapeutic agents. It is primarily utilized by research institutions and pharmaceutical manufacturers engaged in the development of potent anti-infective and anti-cancer drugs.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex macrolide-based active pharmaceutical ingredients (APIs).
• Antibiotic Research: Used in the research and development of next-generation antibiotics targeting resistant bacterial strains.
• Oncology Drug Discovery: Serves as a precursor in the development of novel chemotherapeutic agents with cytotoxic properties.
• Biochemical Research: Employed in academic and industrial laboratories for studying structure-activity relationships (SAR) of complex natural products.
• Process Chemistry Development: Used for scaling up and optimizing synthetic routes for complex molecules in pilot plants.
• Reference Standard: Acts as a high-purity analytical standard for quality control and method validation in pharmaceutical analysis.

Basic Information

Item	Details
Product Name	Acetic acid, 2,2-(1S,3S,7R,8E,11S,12S,15S,17R,21R,23R,25S)-12,25-bis(acetyloxy)-1,11,21-trihydroxy-17-(1R)-1-hydroxyethyl-10,10,26,26-tetramethyl-19-oxo-18,27,28,29-tetraoxatetracyclo21.3.1.13,7.111,15nonacos-8-ene-5,13-diylidenebis-, dimethyl ester, (25Z)
CAS No.	97850-05-0
Molecular Formula	C41H60O16
Molecular Weight	808.91 g/mol
Synonyms	9-Dihydro-9-deoxo-9a-aza-9a-methyl-9a-homoerythromycin A 6,9; 2'-Hemiketal; Azithromycin Impurity L (EP); Azithromycin Related Compound L (USP); (2'R)-2'-Deoxy-2'-(hydroxymethyl)azithromycin; Azithromycin 2'-Hemiketal; 9a-Homo-9a-methyl-9-deoxo-9a-aza-9-dihydroerythromycin A 6,9-2'-hemiketal; Azithromycin 2'-Ketal Impurity
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict GMP (Good Manufacturing Practice) guidelines to ensure batch-to-batch consistency and traceability. Every lot undergoes comprehensive analytical characterization, including HPLC, NMR, and MS, to confirm identity and purity. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting compliance with client-specific or in-house specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. Keep away from strong acids and oxidizing agents. For long-term storage, consider inert gas purging to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single unknown impurity ≤ 1.0%
Water Content (KF)	≤ 3.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.