Description

(Z)-5-[(Dichlorophosphinyl)amino]-α-(ethoxyimino)-1,2,4-thiadiazol-3-acetyl chloride, also known as its (alphaZ) isomer, is a highly reactive and specialized organophosphorus intermediate of significant importance in advanced synthetic chemistry. Its core value lies in its unique molecular architecture, which makes it a critical building block for constructing complex heterocyclic systems. This compound is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients. Its precise stereochemistry and functional groups enable the creation of targeted molecules with specific biological activities.

Application

This advanced chemical intermediate serves as a key precursor in several high-value synthetic pathways. Its primary applications include:

• Pharmaceutical Intermediate: Synthesis of novel drug candidates, particularly those targeting infectious diseases or requiring complex heterocyclic cores.
• Agrochemical Research: Building block for developing new generations of herbicides, fungicides, or insecticides with unique modes of action.
• Chemical Biology & Proteomics: Potential use in creating activity-based probes or affinity labels due to its reactive acyl chloride and phosphorus groups.
• Material Science: Research into novel polymers or ligands where the thiadiazole and phosphinyl groups impart specific electronic or coordination properties.
• Custom Synthesis & Contract Manufacturing: Sourcing for bespoke chemical synthesis projects requiring this specific, high-purity intermediate.

Basic Information

Product Name	(Z)-5-[(Dichlorophosphinyl)amino]-α-(ethoxyimino)-1,2,4-thiadiazol-3-acetyl chloride / (alphaZ)-5-[(Dichlorophosphinyl)amino]-α-(ethoxyimino)-1,2,4-thiadiazol-3-acetyl chloride
CAS No.	90211-01-1
Molecular Formula	C7H8Cl3N4O3PS
Molecular Weight	365.55 g/mol
Synonyms	5-[(Dichlorophosphinyl)amino]-α-(ethoxyimino)-1,2,4-thiadiazole-3-acetyl chloride (Z)-; (alphaZ)-5-[(Dichlorophosphinyl)amino]-α-(ethoxyimino)-1,2,4-thiadiazole-3-acetyl chloride; 1,2,4-Thiadiazol-3-acetyl chloride, 5-[(dichlorophosphinyl)amino]-α-(ethoxyimino)-, (alphaZ)-; CAS 90211-01-1; Phosphoramidochloridate intermediate
EINECS	Contact for details

Quality Control

We supply this high-value intermediate with a strong commitment to purity and batch-to-batch consistency. Our quality control protocols are designed to meet the stringent requirements of research and process development. Each batch is analyzed using advanced techniques including HPLC, NMR, and IR spectroscopy to confirm identity and purity. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to ensure full traceability and support your regulatory documentation.

Storage

Preserve in a tightly closed container, protected from light. Due to its hygroscopic (moisture-sensitive) nature and reactivity as a strong acid/organic solvent derivative, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) in a cool, dry place. Recommended storage temperature is between 2°C and 8°C to maintain stability. Ensure the storage area is well-ventilated and separate from bases and oxidizing agents.

Specification

Item	Specification
Appearance	White to off-white crystalline solid or powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0% (Area %)
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.