Description

(S)-VAPOL phosphoric acid, (S)-2,2'-Diphenyl-3,3'-biphenanthryl-4,4'-diyl phosphate, (S)-18-Hydroxy-8,9-diphenyl-diphenanthro[4,3-d:3',4'-f][1,3,2]dioxaphosphepin-18-oxide is a highly specialized, enantiomerically pure organocatalyst belonging to the VAPOL ligand family. It matters as a crucial chiral auxiliary for inducing stereoselectivity in asymmetric synthesis, enabling the production of single-enantiomer compounds with high optical purity. This product is essential for R&D chemists and process development scientists in the pharmaceutical, agrochemical, and fine chemical industries who require reliable and effective catalysts for complex transformations.

Application

• Asymmetric Catalysis: As a chiral phosphoric acid catalyst for enantioselective reactions such as Friedel-Crafts alkylations, Mannich reactions, and transfer hydrogenations.
• Pharmaceutical Intermediate Synthesis: For the stereocontrolled construction of chiral active pharmaceutical ingredients (APIs) and key intermediates.
• Agrochemical Development: In the synthesis of enantiomerically pure herbicides, fungicides, and plant growth regulators.
• Academic & Industrial Research: A valuable tool for methodological development in organic chemistry and new reaction discovery.
• Ligand for Metal Complexes: Can be used to generate chiral metal catalysts for additional asymmetric transformations.
• Fine Chemical Production: For manufacturing high-value chiral flavors, fragrances, and electronic chemicals.

Basic Information

Product Name	(S)-VAPOL Phosphoric Acid
CAS No.	871130-17-5
Molecular Formula	C52H34O4P
Molecular Weight	753.80 g/mol
Synonyms	(S)-VAPOL Phosphoric Acid; (S)-2,2'-Diphenyl-3,3'-biphenanthryl-4,4'-diyl hydrogen phosphate; (S)-18-Hydroxy-8,9-diphenyl-diphenanthro[4,3-d:3',4'-f][1,3,2]dioxaphosphepin-18-oxide; (S)-3,3'-Bis(9-phenanthryl)-1,1'-binaphthyl-2,2'-diyl hydrogenphosphate; VAPOL-Phosphoric Acid (S-isomer); (aS)-VAPOL Phosphoric Acid; (S)-VAPOL-PA; (S)-VAPOL-derived Phosphoric Acid Catalyst
EINECS	Contact for details

Quality Control

Our (S)-VAPOL phosphoric acid is produced under strict quality-controlled conditions to ensure batch-to-batch consistency and high enantiomeric purity. Each lot is characterized by advanced analytical techniques including HPLC, NMR, and polarimetry. Certificates of Analysis (COA) detailing identity, purity, chiral purity (ee%), and impurity profiles are provided with every shipment to support your quality assurance and regulatory documentation needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.