Description

(1R,3Z,4S,4aα,6R,8aβ,9S,10R)-3,4,4a,5,6,7,8,8a-Octahydro-4,6,9-trihydroxy-3-(hydroxymethylene)-1,6,8β,9-tetramethyl-10-[(R)-1-methylpropyl]-1,4-ethanonaphthalen-2(1H)-one is a complex, high-purity sesquiterpenoid compound of significant interest in advanced organic synthesis and pharmaceutical research. Its intricate stereochemistry and functional groups make it a valuable chiral building block for the development of novel therapeutic agents and fine chemicals. This compound is primarily sought after by research institutions, pharmaceutical R&D laboratories, and specialty chemical manufacturers engaged in the synthesis of complex natural products and bioactive molecules.

Application

• Pharmaceutical Intermediate: Serves as a key chiral precursor in the synthesis of novel drug candidates, particularly in oncology and anti-inflammatory research.
• Advanced Organic Synthesis: Used as a sophisticated building block for constructing complex natural product analogs and macrocyclic compounds.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies to explore new bioactive chemical space.
• Asymmetric Catalysis Studies: Acts as a substrate or ligand precursor in the development of new stereoselective synthetic methodologies.
• Reference Standard: Provides a high-purity analytical standard for quality control and method development in pharmaceutical analysis.
• Biochemical Research: Investigated for potential interactions with biological targets and enzyme systems.

Basic Information

Product Name	(1R,3Z,4S,4aα,6R,8aβ,9S,10R)-3,4,4a,5,6,7,8,8a-Octahydro-4,6,9-trihydroxy-3-(hydroxymethylene)-1,6,8β,9-tetramethyl-10-[(R)-1-methylpropyl]-1,4-ethanonaphthalen-2(1H)-one
CAS No.	85269-22-3
Molecular Formula	C₂₀H₃₂O₅
Molecular Weight	352.47 g/mol
Synonyms	2(1H)-Naphthalenone, 3,4,4a,5,6,7,8,8a-octahydro-4,6,9-trihydroxy-3-(hydroxymethylene)-1,6,8β,9-tetramethyl-10-[(1R)-1-methylpropyl]-1,4-ethano-, (1R,3Z,4S,4aα,6R,8aβ,9S,10R)-; 1,4-Ethanonaphthalen-2(1H)-one derivative; Sesquiterpenoid building block; Chiral sesquiterpene ketone; (R)-Isomer of a polyhydroxy ethanonaphthalenone.
EINECS	Contact for details

Quality Control

Our high-purity pharmaceutical-grade material is produced under strict quality management systems. Each batch undergoes comprehensive analytical characterization including HPLC for purity, chiral analysis, and spectroscopic identification (NMR, IR, MS) to ensure structural integrity and stereochemical fidelity. Certificates of Analysis (COA) detailing all specifications are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider storage under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.