Description

(1aR,2S,5aR,8S,9aR,11R,11aR)-8-(Acetyloxy)-1a,2,3,4,5a,6,7,8,9,9a,10,11-dodecahydro-11-hydroxy-5a,9,9-trimethyl-13-methylene-5H-2,11a-ethanobenzo[5,6]cyclodec[1,2-b]oxirene-5,12-dione is a complex diterpenoid derivative with a unique polycyclic framework, serving as a high-value intermediate for advanced chemical synthesis. Its intricate stereochemistry and functional groups make it a critical building block for research and development in specialized pharmaceutical and agrochemical applications. This compound is primarily sought by R&D chemists and process development scientists working on novel active ingredients and complex natural product analogs.

Application

• Pharmaceutical Intermediate: Key starting material or advanced intermediate in the synthesis of novel drug candidates, particularly those with complex polycyclic structures.
• Agrochemical Research: Used in the development of new pesticides or herbicides, leveraging its bioactive diterpenoid skeleton.
• Natural Product Synthesis: Serves as a sophisticated precursor for the total or semi-synthesis of complex natural products and their derivatives for biological evaluation.
• Chemical Biology Probe Development: Utilized to create specialized molecular probes for studying biological pathways and target engagement.
• Process Chemistry & Scale-Up: Employed in route scouting and optimization studies for the commercial production of high-value fine chemicals.
• Academic & Institutional Research: Used in universities and research institutes for methodological studies in organic synthesis and stereochemistry.

Basic Information

Product Name	(1aR,2S,5aR,8S,9aR,11R,11aR)-8-(Acetyloxy)-1a,2,3,4,5a,6,7,8,9,9a,10,11-dodecahydro-11-hydroxy-5a,9,9-trimethyl-13-methylene-5H-2,11a-ethanobenzo[5,6]cyclodec[1,2-b]oxirene-5,12-dione
CAS No.	83159-27-7
Molecular Formula	C24H30O7
Molecular Weight	430.49 g/mol
Synonyms	8-Acetoxy Grayanotoxin III; Grayanotoxin III 8-acetate; 8-Acetyl Grayanotoxin III; (1aR,2S,5aR,8S,9aR,11R,11aR)-8-Acetyloxy-1a,2,3,4,5a,6,7,8,9,9a,10,11-dodecahydro-11-hydroxy-5a,9,9-trimethyl-13-methylene-5H-2,11a-ethanobenzo[5,6]cyclodec[1,2-b]oxirene-5,12-dione; 8-O-Acetylgrayanotoxin III; Grayanotoxin III acetate
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality control protocols to ensure batch-to-batch consistency and high purity, critical for sensitive synthetic applications. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles. We support cGMP-compliant manufacturing for pharmaceutical applications upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The container should be kept in a well-ventilated area and protected from moisture. For long-term storage, consider inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0%
Any single unknown impurity	≤ 1.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.