Description

(1aR)-8β-Acetyloxy-1,1aα,1bβ,1cα,2a,3,3a,6aα,6b,7,8,8a-dodecahydro-3aβ,6bα,8aα-trihydroxy-2aα-hydroxymethyl-1,1,5,7α-tetramethyl-4H-cyclopropa[5',6']benz[1',2':7,8]azuleno[5,6-b]oxiren-4-one is a complex, high-purity diterpenoid derivative characterized by its intricate polycyclic structure containing an oxirane ring. This compound is of significant interest for advanced research and development, particularly in the pharmaceutical and life sciences sectors, due to its potential as a key synthetic intermediate or a scaffold for novel bioactive molecules. It is primarily sought by research institutions, pharmaceutical development laboratories, and fine chemical manufacturers engaged in the synthesis of complex natural product analogs or targeted therapeutic agents.

Application

• Pharmaceutical Research & Development: Serves as a critical intermediate in the synthesis of novel drug candidates, particularly for exploring anti-inflammatory, antiviral, or anticancer activities.
• Medicinal Chemistry: Used as a sophisticated building block or a core scaffold for structure-activity relationship (SAR) studies and lead optimization programs.
• Natural Product Synthesis: Acts as a key intermediate in the total or semi-synthesis of complex diterpenoid natural products and their derivatives.
• Biochemical Research: Employed in studies investigating enzyme inhibition or modulation of specific biological pathways due to its unique structural features.
• Fine Chemical Production: Utilized in the multi-step synthesis of high-value, specialized chemicals for advanced material or agrochemical research.
• Reference Standard: Supplied as a high-purity analytical standard for method development, quality control, and identification in research settings.

Basic Information

Product Name	(1aR)-8β-Acetyloxy-1,1aα,1bβ,1cα,2a,3,3a,6aα,6b,7,8,8a-dodecahydro-3aβ,6bα,8aα-trihydroxy-2aα-hydroxymethyl-1,1,5,7α-tetramethyl-4H-cyclopropa[5',6']benz[1',2':7,8]azuleno[5,6-b]oxiren-4-one
CAS No.	77573-35-4
Molecular Formula	C25H34O8
Molecular Weight	462.53 g/mol
Synonyms	8β-Acetoxy-3aβ,6bα,8aα-trihydroxy-2aα-hydroxymethyl-1,1,5,7α-tetramethyl-1,1a,1b,1c,2,2a,3,3a,4,5,6,6a,6b,7,8,8a-hexadecahydro-4H-cyclopropa[5',6']benz[1',2':7,8]azuleno[5,6-b]oxirene-4-one; 8β-Acetyloxy Grayanotoxin Derivative; Diterpenoid Oxirane Derivative; 77573-35-4; Grayanotoxin III 8-acetate derivative; (1aR,1bS,2aR,3aR,6aS,6bR,7R,8S,8aR)-8β-Acetyloxy-1,1a,1b,1c,2,2a,3,3a,4,5,6,6a,6b,7,8,8a-hexadecahydro-3a,6b,8a-trihydroxy-2a-(hydroxymethyl)-1,1,5,7-tetramethyl-4H-cyclopropa[5',6']benz[1',2':7,8]azuleno[5,6-b]oxiren-4-one
EINECS	Contact for details

Quality Control

Our (1aR)-8β-Acetyloxy-1,1aα,1bβ,1cα,2a,3,3a,6aα,6b,7,8,8a-dodecahydro-3aβ,6bα,8aα-trihydroxy-2aα-hydroxymethyl-1,1,5,7α-tetramethyl-4H-cyclopropa[5',6']benz[1',2':7,8]azuleno[5,6-b]oxiren-4-one is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via spectroscopic methods (NMR, MS), to ensure it meets exacting research-grade specifications. Comprehensive Certificates of Analysis (COA) detailing all test results are provided to guarantee traceability and batch-to-batch consistency for your critical research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive); the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.