Description

(E)-2-Methyl-2-butenoic acid [(1aR,2S,4E,7R,7aR,8S,10aS,10bR)-1a,2,3,6,7,7a,8,9,10a,10b-decahydro-2-hydroxy-1a,5,8-trimethyl-9-oxooxireno[9,10]cyclodeca[1,2-b]furan-7-yl] ester is a high-purity, complex organic ester with a defined stereochemistry, making it a critical advanced intermediate for sophisticated chemical synthesis. Its value lies in its precise molecular architecture, which is essential for constructing complex pharmacophores and natural product analogs. This compound is primarily needed by pharmaceutical R&D and fine chemical manufacturers engaged in the development of novel active ingredients and specialty materials.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of complex drug candidates, particularly in oncology and anti-infective research.
• Natural Product Synthesis: Used in the laboratory-scale and pilot-scale synthesis of complex natural products and their derivatives for biological evaluation.
• Chemical Biology Probe Development: Acts as a precursor for creating molecular probes to study specific biological pathways and enzyme functions.
• Advanced Material Research: Potential intermediate for developing specialty polymers or liquid crystals with specific optical or structural properties.
• Process Chemistry Development: Employed in route scouting and optimization for the scalable production of high-value target molecules.

Basic Information

Product Name	(E)-2-Methyl-2-butenoic acid [(1aR,2S,4E,7R,7aR,8S,10aS,10bR)-1a,2,3,6,7,7a,8,9,10a,10b-decahydro-2-hydroxy-1a,5,8-trimethyl-9-oxooxireno[9,10]cyclodeca[1,2-b]furan-7-yl] ester
CAS No.	62197-60-8
Molecular Formula	C22H30O6
Molecular Weight	390.47 g/mol
Synonyms	2-Methylcrotonic Acid Artemisinyl Ester; Tiglic Acid Artemisinyl Ester; (E)-2-Methylbut-2-enoic acid artemisinin derivative; Artemisinin tiglate; Arteannuin B tiglate ester; (3R,5aS,6R,8aS,9R,10S,12R,12aR)-Octahydro-3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2-benzodioxepin-10-yl (E)-2-methylbut-2-enoate
EINECS	Contact for details

Quality Control

Every batch of our (E)-2-Methyl-2-butenoic acid artemisinyl ester is produced and controlled under a strict quality management system. We provide comprehensive analytical data to ensure identity, purity, and consistency for your critical research and development projects. Certificates of Analysis (COA) detailing specifications such as chiral purity, assay, and related substances are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). The compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Loss on Drying	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.