Description

(1R,3S,5R,6R,9R,11R,15S,16S,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35 S,36S,37S)-33-[(2S,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyl-oxan-2- yl]oxy-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39- dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-car boxylic acid, (2R,3R,4R,5S)-6-methylaminohexane-1,2,3,4,5-pentol is a structurally complex macrolide compound with significant biological activity. This high-purity chemical is critical for research and development in advanced pharmaceutical applications, particularly in the study of novel therapeutic mechanisms. It is primarily sought by biotechnology firms, academic research institutions, and pharmaceutical companies engaged in the discovery of new active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Research & Development: Serves as a key intermediate or reference standard in the synthesis and study of novel antibiotic and antifungal agents.
• Biochemical Research: Used as a potent tool compound to investigate specific enzymatic pathways and cellular processes in microbiology and molecular biology.
• API Development: Acts as a critical building block or precursor in the development and scale-up of new Active Pharmaceutical Ingredients (APIs) with complex polyketide structures.
• Reference Standard: Employed as a high-purity analytical standard for quality control and method validation in pharmaceutical manufacturing and regulatory testing.
• Academic Studies: Utilized in university and institutional labs for chemical synthesis methodology research and structure-activity relationship (SAR) studies.

Basic Information

Product Name	(1R,3S,5R,6R,9R,11R,15S,16S,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35 S,36S,37S)-33-[(2S,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyl-oxan-2- yl]oxy-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39- dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-car boxylic acid, (2R,3R,4R,5S)-6-methylaminohexane-1,2,3,4,5-pentol
CAS No.	59241-53-1
Molecular Formula	C46H75NO20
Molecular Weight	962.1 g/mol
Synonyms	Amphotericin B Methyl Ester; Amphotericin B Me ester; Amphotericin B Methyl Ester Dihydrochloride; NSC 330770; Antibiotic X-68; Fungizone Methyl Ester; (35R)-33-[(4-Amino-3,5-dihydroxy-6-methyloxan-2-yl)oxy]-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39-dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-carboxylic acid methyl ester
EINECS	Contact for details

Quality Control

Our (1R,3S,5R,6R,9R,11R,15S,16S,17R,18S,19E,21E,23E,25E,27E,29E,31E,33R,35 S,36S,37S)-33-[(2S,3S,4S,5S,6R)-4-amino-3,5-dihydroxy-6-methyl-oxan-2- yl]oxy-1,3,5,6,9,11,17,37-octahydroxy-15,16,18-trimethyl-13-oxo-14,39- dioxabicyclo[33.3.1]nonatriaconta-19,21,23,25,27,29,31-heptaene-36-car boxylic acid, (2R,3R,4R,5S)-6-methylaminohexane-1,2,3,4,5-pentol is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for research and development use. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry, inert environment. Due to its hygroscopic nature, containers must be sealed under anhydrous conditions after each use to prevent moisture absorption and degradation. For long-term stability, store desiccated.

Specification

Item	Specification
Appearance	Yellow to orange powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.