Description

[(2R,3S,4R,6S)-4-dimethylamino-2-[[(1S,2E,5R,7R,8R,9S,10R,14S,15R,16R)-14-ethyl-10-hydroxy-1,5,9,15-tetramethyl-4,12-dioxo-7-(2-oxoethyl)-13,17-dioxabicyclo[14.1.0]heptadec-2-en-8-yl]oxy]-6-methyl-oxan-3-yl] butanoate is a complex, high-purity macrolide derivative of significant interest in advanced pharmaceutical research and development. This compound matters as a critical intermediate or reference standard for the synthesis and analysis of novel therapeutic agents, particularly in the field of antibiotics and anti-infectives. It is essential for research institutions, pharmaceutical companies, and contract development and manufacturing organizations (CDMOs) engaged in the discovery of new bioactive molecules and the quality control of complex active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: Serves as a key building block in the multi-step synthesis of novel macrolide antibiotics and other complex therapeutic agents.
• Reference Standard: Used as a high-purity analytical standard in HPLC, LC-MS, and NMR for method development, validation, and quality control of related APIs.
• Biochemical Research: Employed in academic and industrial research to study structure-activity relationships (SAR), microbial resistance mechanisms, and the biosynthesis of complex natural products.
• Process Development & Scale-up: Critical for process chemistry teams optimizing synthetic routes for cost-effective and scalable production of target molecules.
• Impurity Profiling: Utilized to identify, characterize, and quantify process-related impurities and degradation products in macrolide-based drug substances.

Basic Information

Product Name	[(2R,3S,4R,6S)-4-dimethylamino-2-[[(1S,2E,5R,7R,8R,9S,10R,14S,15R,16R)-14-ethyl-10-hydroxy-1,5,9,15-tetramethyl-4,12-dioxo-7-(2-oxoethyl)-13,17-dioxabicyclo[14.1.0]heptadec-2-en-8-yl]oxy]-6-methyl-oxan-3-yl] butanoate
CAS No.	55103-30-5
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	9-Dihydro-9-deoxo-12,13-bisepi-11-deoxy-11-(carboxyethylidene)-erythromycin A 2'-acetate, 4''-butanoate; Erythromycin derivative (55103-30-5); 11-Deoxy-11-(2-carboxyethylidene)-6-O-methyl-11,12-dideoxy-6,12-epoxy-7,13-didehydro-13-oxoerythromycin A 2'-acetate, 4''-butanoate; 6-O-Methylerythromycin A 11,12-carbonate 2'-acetate, 4''-butanoate derivative; (2'R,3S,4R,6S)-4-(Dimethylamino)-2-{[(1S,2E,5R,7R,8R,9S,10R,14S,15R,16R)-14-ethyl-10-hydroxy-1,5,9,15-tetramethyl-4,12-dioxo-7-(2-oxoethyl)-13,17-dioxabicyclo[14.1.0]heptadec-2-en-8-yl]oxy}-6-methyltetrahydro-2H-pyran-3-yl butanoate
EINECS	Contact for details

Quality Control

Our [(2R,3S,4R,6S)-4-dimethylamino-2-[[(1S,2E,5R,7R,8R,9S,10R,14S,15R,16R)-14-ethyl-10-hydroxy-1,5,9,15-tetramethyl-4,12-dioxo-7-(2-oxoethyl)-13,17-dioxabicyclo[14.1.0]heptadec-2-en-8-yl]oxy]-6-methyl-oxan-3-yl] butanoate is produced under a strict quality management system. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the stringent requirements for pharmaceutical research and development. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting batch-specific results.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label. Due to its sensitivity, the product should be stored under an inert atmosphere (e.g., nitrogen or argon) to prevent oxidation. Keep the container tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time corresponds to reference standard
Assay (HPLC)	≥ 95.0%
Related Substances (HPLC)	Total impurities ≤ 5.0% Any single impurity ≤ 2.0%
Residual Solvents (GC)	Complies with ICH Q3C guidelines
Water Content (KF)	≤ 5.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.