Description

Propanoic acid, 3-[(1S)-1-[(1S,3aS,4E,7aS)-4-[(2Z)-[(3S,5R)-3,5-bis[[(1,1-diMethylethyl)dimethylsilyl]oxy]-2-Methylenecyclohexylidene]ethylidene]octahydro-7a-Methyl-1H-inden-1-yl]ethoxy]-, ethyl ester is a highly specialized, advanced pharmaceutical intermediate characterized by its complex steroidal-like structure with multiple chiral centers and protecting groups. This compound is of critical importance for its role in the synthesis of novel therapeutic agents, particularly in the development of vitamin D analogs and other high-value, biologically active molecules. It is essential for research institutions and pharmaceutical manufacturers engaged in cutting-edge drug discovery and process chemistry.

Application

• Key Intermediate in Vitamin D Analog Synthesis: Serves as a crucial building block in the multi-step synthesis of calcitriol derivatives and other secosteroids.
• Pharmaceutical Research & Development (R&D): Used in exploratory chemistry for developing new drug candidates targeting nuclear hormone receptors.
• Process Chemistry & Scale-Up: Employed in optimizing synthetic routes for the production of target active pharmaceutical ingredients (APIs) at pilot and commercial scales.
• Academic Research: Utilized in university and institutional labs for studying structure-activity relationships (SAR) and synthetic methodology.
• Reference Standard: Can be supplied as a high-purity standard for analytical method development and quality control in API manufacturing.

Basic Information

Product Name	Propanoic acid, 3-[(1S)-1-[(1S,3aS,4E,7aS)-4-[(2Z)-[(3S,5R)-3,5-bis[[(1,1-diMethylethyl)dimethylsilyl]oxy]-2-Methylenecyclohexylidene]ethylidene]octahydro-7a-Methyl-1H-inden-1-yl]ethoxy]-, ethyl ester
CAS No.	413571-27-4
Molecular Formula	C41H74O4Si2
Molecular Weight	687.2 g/mol
Synonyms	Ethyl (S)-3-((S)-1-((1S,3aS,4E,7aS)-4-((Z)-((3S,5R)-3,5-Bis((tert-butyldimethylsilyl)oxy)-2-methylenecyclohexylidene)ethylidene)-7a-methyloctahydro-1H-inden-1-yl)ethoxy)propanoate; (1S,3aS,4E,7aS)-1-[(1S)-1-[[(Ethoxycarbonyl)ethyl]oxy]ethyl]-7a-methyl-4-[(2Z)-[(3S,5R)-3,5-bis[[(1,1-dimethylethyl)dimethylsilyl]oxy]-2-methylene-1-cyclohexylidene]ethylidene]octahydro-1H-indene; Vitamin D Intermediate; TBS-protected Vitamin D analog precursor; Secosteroid synthesis intermediate.
EINECS	Contact for details

Quality Control

This high-value intermediate is manufactured under strict quality management systems. Every batch is characterized using advanced analytical techniques to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) detailing chiral purity, chemical purity, and impurity profiles. Our production adheres to cGMP guidelines where applicable, ensuring reliability for critical pharmaceutical development work.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label or COA. This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when opening to prevent degradation. Keep away from strong acids and organic solvents.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC/IR)	Conforms to reference standard
Assay (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% de
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.