[(2-{Bis[3,5-bis(trifluoromethyl)phenyl]phosphine}-3,6-dimethoxy- 2′,4′,6′- triisopropyl-1,1′-biphenyl )-2-(2′-amino-1,1′-biphenyl)]palladium(II) methanesulfonate CAS NO 2102544-35-2

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CAS No.:2102544-35-2

Grade:Pharmacy Grade

Content:99.9%

Brand:Customizable

Packaging:Customizable

Description

[(2-{Bis[3,5-bis(trifluoromethyl)phenyl]phosphine}-3,6-dimethoxy- 2′,4′,6′- triisopropyl-1,1′-biphenyl )-2-(2′-amino-1,1′-biphenyl)]palladium(II) methanesulfonate CAS NO 2102544-35-2 is a highly specialized, Buchwald-type palladium precatalyst designed for demanding cross-coupling reactions. This compound matters because it offers exceptional air stability and high catalytic activity, eliminating the need for handling sensitive ligand-palladium mixtures in-house. It is primarily needed by research and development chemists in the pharmaceutical and advanced materials sectors for synthesizing complex organic molecules, including active pharmaceutical ingredients (APIs) and functional polymers.

Application

Pharmaceutical Intermediate Synthesis: Key catalyst for Buchwald-Hartwig amination and Suzuki-Miyaura cross-coupling in API development.
Advanced Materials Research: Facilitating C-N and C-C bond formation in the creation of novel organic electronic materials and ligands.
Process Chemistry & Scale-up: Used in optimized routes for the commercial-scale production of fine chemicals due to its reliability and defined composition.
Methodology Development: A preferred precatalyst in academic and industrial labs for developing new catalytic transformations under mild conditions.
Synthesis of Biaryl Compounds: Enables efficient coupling of aryl halides with amines or boronates to construct complex biaryl structures.

Basic Information


Product Name	[(2-{Bis[3,5-bis(trifluoromethyl)phenyl]phosphine}-3,6-dimethoxy- 2′,4′,6′- triisopropyl-1,1′-biphenyl )-2-(2′-amino-1,1′-biphenyl)]palladium(II) methanesulfonate
CAS No.	2102544-35-2
Molecular Formula	C58H55F12NO5PPdS
Molecular Weight	~1240.0 g/mol (Contact for exact details)
Synonyms	BrettPhos Palladium Precatalyst Methanesulfonate; [(2-Dicyclohexylphosphino-2′,4′,6′-triisopropyl-1,1′-biphenyl)-2-(2′-amino-1,1′-biphenyl)]palladium(II) methanesulfonate (common misnomer); Pd(AmPhos)(BrettPhos) methanesulfonate; Buchwald Palladium Precatalyst G4; Palladium(II) methanesulfonate complex with BrettPhos and biphenyl-2-amine; Pd-BrettPhos-amine Mesylate; (AmPhos)Pd(BrettPhos) Mesylate; CAS 2102544-35-2.
EINECS	Contact for details

Quality Control

Every batch of our palladium precatalyst is manufactured and tested under strict quality control protocols to ensure consistent, high-performance material for critical synthesis. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as palladium content, purity by HPLC/NMR, and residual solvent levels. Our quality system is designed to meet the exacting standards of pharmaceutical R&D and process chemistry.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C to -10°C under an inert atmosphere (argon or nitrogen) for long-term stability. This material is easily oxidized (store under inert atmosphere) and light-sensitive (store away from light). Allow the sealed container to reach room temperature before opening to prevent moisture condensation.

Specification

Item	Specification
Appearance	Yellow to orange-brown solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Palladium (Pd) Content	7.0 - 9.0 %
Water Content (KF)	≤ 1.0 %
Residual Solvents (GC)	Meets ICH guidelines