Description

2-[[(3aR,4S,6R,6aS)-6-[7-Bromo-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-acetic acid methyl ester is a high-purity, advanced pharmaceutical intermediate characterized by its complex heterocyclic structure. This compound is of significant value for research and development in medicinal chemistry, particularly in the synthesis of novel nucleoside analogs and antiviral or anticancer agents. It is primarily sought by pharmaceutical R&D laboratories, biotechnology companies, and fine chemical manufacturers engaged in the development of targeted therapeutics.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel nucleoside and nucleotide analogs for antiviral and anticancer drug discovery.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new active pharmaceutical ingredients (APIs) targeting viral polymerases or specific enzymes.
• Bioconjugation & Probe Development: The reactive ester group and unique heterocyclic core make it suitable for creating biochemical probes and diagnostic agents.
• Process Chemistry & Scale-up: Serves as a critical intermediate in the optimization and commercial-scale production of complex therapeutic molecules.
• Academic & Institutional Research: Utilized in university and government labs for fundamental research in organic synthesis and bioorganic chemistry.

Basic Information

Product Name	2-[[(3aR,4S,6R,6aS)-6-[7-Bromo-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]tetrahydro-2,2-dimethyl-4H-cyclopenta-1,3-dioxol-4-yl]oxy]-acetic acid methyl ester
CAS No.	274693-24-2
Molecular Formula	C18H23BrN4O5S
Molecular Weight	487.37 g/mol
Synonyms	Methyl 2-(((3aR,4S,6R,6aS)-6-(7-bromo-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-2,2-dimethyltetrahydrocyclopenta[d][1,3]dioxol-4-yl)oxy)acetate; 7-Bromo-5-(propylthio)-3-((3aR,4S,6R,6aS)-4-((2-methoxy-2-oxoethoxy)methyl)-2,2-dimethyltetrahydrocyclopenta[d][1,3]dioxol-6-yl)-3H-[1,2,3]triazolo[4,5-d]pyrimidine; 274693-24-2; Methyl (2R,3S,4R,5R)-2-(7-bromo-5-propylsulfanyl-triazolo[4,5-d]pyrimidin-3-yl)-5-[(methoxycarbonyl)methoxymethyl]tetrahydrofuran-3,4-diol cyclic acetonide
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems to ensure batch-to-batch consistency and purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity, NMR for structural confirmation, and residual solvent analysis. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting all critical quality attributes. We support development and commercial projects requiring compliance with cGMP standards.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) in a dry, well-ventilated area. The compound is moisture-sensitive; keep the container tightly sealed under an inert atmosphere for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Conforms to reference standard
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 0.5%
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.