Description

N-[(1S,2R,3E,5E,7S,9E,11E,13S,15R,19R)-7-Hydroxy-1,4,10,19-tetramethyl-17,18-dioxo-13-(1-oxopropoxy)-16-oxabicyclo[13.2.2]nonadeca-3,5,9,11-tetrene-2-yl]-2-oxopropanamide is a complex, high-purity macrolide derivative with significant biological activity. This compound is valued for its role as a critical advanced pharmaceutical intermediate in the synthesis of novel therapeutic agents. It is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of potent anti-infective and anti-cancer drugs, where precise molecular structure is paramount for efficacy.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of complex macrolide-based antibiotics and chemotherapeutic agents.
• Biomedical Research: Used as a reference standard and active compound in pharmacological studies targeting specific cellular pathways.
• Drug Discovery: Serves as a core scaffold for medicinal chemistry programs aimed at developing new molecular entities with enhanced therapeutic profiles.
• Pre-clinical Development: Employed in the formulation and testing stages for novel drug candidates prior to clinical trials.
• High-Value Fine Chemical Production: Integral to multi-step synthetic routes for producing specialized, low-volume, high-potency active pharmaceutical ingredients (APIs).

Basic Information

Product Name	N-[(1S,2R,3E,5E,7S,9E,11E,13S,15R,19R)-7-Hydroxy-1,4,10,19-tetramethyl-17,18-dioxo-13-(1-oxopropoxy)-16-oxabicyclo[13.2.2]nonadeca-3,5,9,11-tetrene-2-yl]-2-oxopropanamide
CAS No.	28268-50-0
Molecular Formula	C30H39NO8
Molecular Weight	541.64 g/mol
Synonyms	7-Hydroxy-1,4,10,19-tetramethyl-17,18-dioxo-13-(1-oxopropoxy)-16-oxabicyclo[13.2.2]nonadeca-3,5,9,11-tetrene-2-carboxamide, N-(2-oxopropanoyl) derivative; Macrolactam Derivative; Bicyclic Macrolide Intermediate; (1S,2R,3E,5E,7S,9E,11E,13S,15R,19R)-Isomer of the specified amide.
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and traceability. Quality is verified through comprehensive analytical techniques including HPLC, NMR, and mass spectrometry to confirm identity, purity, and isomeric composition. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting all critical specifications. We support development under cGMP guidelines where required.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as specified on the label or COA. The compound is moisture-sensitive; keep the container in a dry environment. For long-term storage, consider under an inert atmosphere to preserve stability.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Specific Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.