Description

Methyl [(2S)-3-methyl-1-[(2S,5S)-2-methyl-5-[9-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,11-dihydroisochromeno[4',3':6,7]naphtho[1,2-d]imidazol-2-yl]pyrrolidin-1-yl]-1-oxobutan-2-yl]carbamate is a sophisticated, high-purity chemical intermediate featuring a complex fused-ring structure with a key boronic ester protecting group. This compound is of significant value in modern pharmaceutical research and development, particularly for its role in Suzuki-Miyaura cross-coupling reactions, a cornerstone methodology for carbon-carbon bond formation. It is primarily utilized by pharmaceutical R&D laboratories and contract research organizations (CROs) engaged in the synthesis of novel small molecule therapeutics, especially those targeting complex biological pathways.

Application

• Pharmaceutical Intermediate: A critical building block in the multi-step synthesis of investigational new drugs (INDs) and active pharmaceutical ingredients (APIs).
• Suzuki-Miyaura Cross-Coupling Reagent: The boronic ester moiety enables efficient palladium-catalyzed coupling with aryl/heteroaryl halides, facilitating the construction of complex biaryl structures common in modern drug candidates.
• Protease Inhibitor Research: The specific stereochemistry and carbamate-protected amino acid-like structure suggest potential application in the development of protease or kinase inhibitors.
• Chemical Biology & Probe Development: Used in the creation of molecular probes for studying enzyme function and protein-protein interactions within biological systems.
• Process Chemistry & Scale-Up: Serves as a key intermediate during the route scouting and optimization phases for potential commercial manufacturing processes.
• Academic Research: Employed in university and institutional laboratories for methodological studies in synthetic organic chemistry and medicinal chemistry.

Basic Information

Item	Details
Product Name	Methyl [(2S)-3-methyl-1-[(2S,5S)-2-methyl-5-[9-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,11-dihydroisochromeno[4',3':6,7]naphtho[1,2-d]imidazol-2-yl]pyrrolidin-1-yl]-1-oxobutan-2-yl]carbamate
CAS No.	1378392-97-2
Molecular Formula	C38H45BN4O6
Molecular Weight	664.60 g/mol
Synonyms	(2S)-2-[[(Methoxy)carbonyl]amino]-3-methylbutanoic acid (2S,5S)-2-methyl-5-[9-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,11-dihydroisochromeno[4',3':6,7]naphtho[1,2-d]imidazol-2-yl]-1-pyrrolidinyl ester; Methyl N-[(2S)-3-methyl-1-oxo-1-[(2S,5S)-2-methyl-5-[9-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1,11-dihydroisochromeno[4',3':6,7]naphtho[1,2-d]imidazol-2-yl]pyrrolidin-1-yl]butan-2-yl]carbamate; Boronic ester intermediate 1378392-97-2; Fused imidazole boronate ester; Isochromenonaphthoimidazole boronic acid pinacol ester derivative.
EINECS	Contact for details

Quality Control

Every batch of this advanced intermediate is produced and tested under a strict quality management system. We guarantee high chemical purity and stereochemical integrity through comprehensive analytical techniques including HPLC, NMR, and MS. A detailed Certificate of Analysis (COA) is provided with each shipment, documenting identity, purity, and impurity profiles to support your regulatory and research needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to ensure long-term stability. Keep the container tightly sealed in a desiccator after opening.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (HPLC)	Retention time corresponds to reference standard
Identification (NMR)	Spectrum consistent with structure
Purity (HPLC)	≥ 95.0%
Assay (by HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.