Description

Chloro(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl] palladium(II) methyl-t-butylether adduct, min. 98% [XPhos Palladacycle Gen. 1] is a highly active, pre-formed palladium catalyst complex designed for superior performance in cross-coupling reactions. This product matters because it offers exceptional stability, ease of handling, and high catalytic efficiency, directly addressing the need for reliable and reproducible results in sensitive synthetic workflows. It is an essential tool for researchers and process chemists in the pharmaceutical, agrochemical, and advanced materials industries who require a robust catalyst for demanding transformations like Buchwald-Hartwig aminations and Suzuki-Miyaura couplings.

Application

• Pharmaceutical Intermediate Synthesis: A key catalyst for C-N and C-C bond formation in the production of active pharmaceutical ingredients (APIs), particularly in late-stage functionalization.
• Buchwald-Hartwig Amination: Enables efficient coupling of amines with aryl halides, a critical step for constructing nitrogen-containing heterocycles and complex amines.
• Suzuki-Miyaura Cross-Coupling: Facilitates the coupling of aryl/vinyl boronic acids with halides for biaryl synthesis in drug discovery and material science.
• Agrochemical Research & Development: Used in the synthesis of novel herbicides, fungicides, and insecticides requiring selective cross-coupling steps.
• Academic & Industrial R&D: A preferred catalyst for method development and exploring new synthetic pathways due to its well-defined activity and air stability.
• Ligand-Accelerated Catalysis: The XPhos ligand provides superior steric and electronic properties, enabling reactions with challenging substrates at lower catalyst loadings.

Basic Information

Product Name	Chloro(2-dicyclohexylphosphino-2',4',6'-tri-i-propyl-1,1'-biphenyl)[2-(2-aminoethyl)phenyl] palladium(II) methyl-t-butylether adduct, min. 98% [XPhos Palladacycle Gen. 1]
CAS No.	1334385-47-5
Molecular Formula	C46H68ClNOPPd
Molecular Weight	824.85 g/mol
Synonyms	XPhos Palladacycle; Chloro[2-(2-aminoethyl)phenyl-C,N][2-(dicyclohexylphosphino)-2',4',6'-triisopropyl-1,1'-biphenyl]palladium(II) Methyl tert-Butyl Ether Adduct; XPhos Pd G1; XPhos Palladacycle First Generation; Pd(XPhos)(o-NH2CH2C6H4)Cl; Palladium(II) XPhos Aminobiphenyl Complex; [2-(2-Aminoethyl)phenyl]chloropalladium-XPhos Complex
EINECS	Contact for details

Quality Control

Our XPhos Palladacycle Gen. 1 is manufactured under strict quality protocols to ensure batch-to-batch consistency and high catalytic performance. Each lot undergoes comprehensive analysis, including NMR, HPLC, and elemental analysis, to verify identity, purity, and absence of deleterious impurities. A detailed Certificate of Analysis (COA) documenting all test results is provided with every shipment to support your quality assurance and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store under an inert atmosphere (argon or nitrogen) at 2-8°C. This material is moisture-sensitive and easily oxidized; prolonged exposure to air or ambient humidity should be avoided to maintain catalytic activity.

Specification

Item	Specification
Appearance	Yellow to orange crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	Min. 98.0%
Palladium (Pd) Content	12.0 - 13.5%
Solubility	Soluble in common organic solvents (DCM, THF, toluene)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.