Description

1H-as-Indaceno3,2-doxacyclododecin-7,15-dione, 2-(6-deoxy-2,3,4-tri-O-methyl-.alpha.-L-mannopyranosyl)oxy-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-14-methyl-13-(2R,5S,6R)-tetrahydro-6-methyl-5-(methylamino)-2H-pyran-2-yloxy-, (2R,3aS is a complex, high-purity macrolide derivative of significant interest in advanced pharmaceutical research and development. Its intricate molecular architecture makes it a valuable intermediate or reference standard for synthesizing novel therapeutic agents, particularly in oncology and anti-infective drug discovery. This compound is essential for research institutions, pharmaceutical R&D laboratories, and fine chemical manufacturers engaged in cutting-edge medicinal chemistry and process development.

Application

• Pharmaceutical Intermediate: Serves as a critical building block in the synthesis of novel macrolide-based active pharmaceutical ingredients (APIs).
• Medicinal Chemistry Research: Used as a key scaffold or precursor in structure-activity relationship (SAR) studies for drug discovery programs.
• Reference Standard: Provides a high-purity benchmark for analytical method development, validation, and quality control in pharmaceutical manufacturing.
• Biochemical Research: Employed in studies investigating biological pathways and mechanisms of action at the molecular level.
• Process Development: Utilized for optimizing synthetic routes and scaling up production of complex molecules in fine chemical synthesis.

Basic Information

Product Name	1H-as-Indaceno3,2-doxacyclododecin-7,15-dione, 2-(6-deoxy-2,3,4-tri-O-methyl-.alpha.-L-mannopyranosyl)oxy-9-ethyl-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-14-methyl-13-(2R,5S,6R)-tetrahydro-6-methyl-5-(methylamino)-2H-pyran-2-yloxy-, (2R,3aS
CAS No.	131929-61-8
Molecular Formula	Contact for details
Molecular Weight	Contact for details
Synonyms	(2R,3aS,5aR,5bS,9S,13S,14R,16aS,16bS)-9-Ethyl-14-methyl-2-{[(2R,5S,6R)-6-methyl-5-(methylamino)tetrahydro-2H-pyran-2-yl]oxy}-13-{[(2R,3R,4R,5R,6S)-3,4,5-trimethoxy-6-methyltetrahydro-2H-pyran-2-yl]oxy}-2,3,3a,5a,5b,6,9,10,11,12,13,14,16a,16b-tetradecahydro-1H-as-indaceno[3,2-d]oxacyclododecine-7,15-dione; CAS 131929-61-8; Macrolide derivative 131929-61-8.
EINECS	Contact for details

Quality Control

Our 1H-as-Indaceno3,2-doxacyclododecin-7,15-dione derivative is produced under a strict quality management system. Each batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing purity (typically by HPLC), identity confirmation (e.g., by IR, NMR), and impurity profiles are provided with every shipment. We can support compliance with cGMP standards for advanced intermediates upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants or an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to reference spectrum
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Single Unknown Impurity (HPLC)	≤ 1.0%
Total Impurities (HPLC)	≤ 5.0%
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.