Description

(1R,2R,3R,6E,8S,9S,12S,14E,16S)-12-hydroxy-2-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyl-oxan-2-yl]oxymethyl]-9-[(2S,3R,4S,6R)-3-hydroxy-4-methoxy-6-methyl-oxan-2-yl]oxy-3,8,12-trimethyl-4,17-dioxabicyclo[14.1.0]heptadeca-6,14-diene-5,13-dione is a complex macrolide compound of significant interest in advanced pharmaceutical research and development. Its intricate stereochemistry and functional groups make it a valuable intermediate or reference standard for the synthesis and study of novel bioactive molecules. This high-purity compound is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors requiring precise, well-characterized building blocks.

Application

• Pharmaceutical Intermediate: Serves as a key chiral building block in the synthesis of complex active pharmaceutical ingredients (APIs), particularly for macrolide-based therapeutics.
• Reference Standard: Used in analytical laboratories for method development, validation, and quality control (QC) of related compounds, ensuring regulatory compliance.
• Medicinal Chemistry Research: A crucial substrate for structure-activity relationship (SAR) studies and the discovery of new drug candidates with targeted biological activity.
• Biochemical Research: Employed in enzymatic studies and as a probe to investigate specific biological pathways and mechanisms of action.
• Process Development: Acts as a benchmark in scaling up synthetic routes from laboratory to pilot and commercial production scales.

Basic Information

Product Name	(1R,2R,3R,6E,8S,9S,12S,14E,16S)-12-hydroxy-2-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyl-oxan-2-yl]oxymethyl]-9-[(2S,3R,4S,6R)-3-hydroxy-4-methoxy-6-methyl-oxan-2-yl]oxy-3,8,12-trimethyl-4,17-dioxabicyclo[14.1.0]heptadeca-6,14-diene-5,13-dione
CAS No.	1404-08-6
Molecular Formula	C34H54O14
Molecular Weight	686.79 g/mol
Synonyms	Oleandomycin; Matromycin; Romicil; Landomycin; Amimycin; PA 105; Antibiotic PA 105; Oleandocycline; (8S)-8-Demethyl-8-hydroxyoleandomycin (partial structure); Macrolide antibiotic PA 105
EINECS	Contact for details

Quality Control

Our (1R,2R,3R,6E,8S,9S,12S,14E,16S)-12-hydroxy-2-[[(2R,3R,4R,5R,6R)-5-hydroxy-3,4-dimethoxy-6-methyl-oxan-2-yl]oxymethyl]-9-[(2S,3R,4S,6R)-3-hydroxy-4-methoxy-6-methyl-oxan-2-yl]oxy-3,8,12-trimethyl-4,17-dioxabicyclo[14.1.0]heptadeca-6,14-diene-5,13-dione is produced and tested under a strict quality management system. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided, documenting results from HPLC, NMR, and other relevant pharmacopeial or in-house methods. We support compliance with cGMP and research-grade standards as required.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm
Specific Optical Rotation	Contact for details

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.