Description

(2R,3R)-3-Amino-3-(3-Fluoro-Phenyl)-2-Hydroxy-Propionic Acid is a high-purity, non-natural amino acid derivative characterized by its specific stereochemistry and fluorine substitution. This compound is a critical chiral building block and intermediate in modern pharmaceutical synthesis, enabling the development of targeted therapeutics. It is primarily utilized by research institutions and manufacturers in the pharmaceutical and fine chemical industries for the development of novel active pharmaceutical ingredients (APIs), particularly in areas such as enzyme inhibitors and peptide mimetics.

Application

• Pharmaceutical Intermediate: A key chiral synthon for the synthesis of novel drug candidates, especially protease inhibitors and other enzyme-targeted therapies.
• Peptidomimetic Research: Serves as a constrained, fluorinated amino acid analog in the design and synthesis of peptide mimetics to enhance metabolic stability and binding affinity.
• Chemical Biology Probes: Used in the development of activity-based probes and labeled compounds for studying biological pathways and target engagement.
• Asymmetric Synthesis: Employed as a starting material or auxiliary in catalytic asymmetric reactions to construct complex molecules with high enantiomeric purity.
• API Development: Integral in the research and process development stages for new Active Pharmaceutical Ingredients requiring fluorinated, chiral amino acid motifs.

Basic Information

Product Name	(2R,3R)-3-Amino-3-(3-Fluoro-Phenyl)-2-Hydroxy-Propionic Acid
CAS No.	959573-06-9
Molecular Formula	C9H10FNO3
Molecular Weight	199.18 g/mol
Synonyms	(2R,3R)-3-Amino-3-(3-fluorophenyl)-2-hydroxypropanoic acid; (R,R)-3-Amino-3-(3-fluorophenyl)-2-hydroxypropionic acid; 3-Amino-3-(3-fluorophenyl)-D-β-hydroxypropionic acid; 3-Fluoro-D-β-hydroxy-phenylalanine; 3-F-D-β-Hydroxy-Phe; β-Hydroxy-3-fluoro-D-phenylalanine; (2R,3R)-3-Amino-2-hydroxy-3-(3-fluorophenyl)propanoic acid; 959573-06-9
EINECS	Contact for details

Quality Control

Our (2R,3R)-3-Amino-3-(3-Fluoro-Phenyl)-2-Hydroxy-Propionic Acid is manufactured under a strict quality management system. Every batch undergoes comprehensive analytical testing, including chiral HPLC for enantiomeric excess and standard pharmacopeial identification tests, to ensure high chemical and chiral purity suitable for advanced synthetic applications. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with customer specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to prevent moisture absorption. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (Chiral HPLC)	≥ 99.0% ee
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.