Description

Dl-Pyroglutamic Acid CAS NO 149-87-1 is a versatile cyclic amino acid derivative, also known as 5-oxoproline, which serves as a key chiral building block and intermediate in organic synthesis. Its significance lies in its role as a precursor for the synthesis of various pharmaceuticals, agrochemicals, and fine chemicals, offering a crucial handle for stereochemical control. This product is essential for research institutions, pharmaceutical manufacturers, and fine chemical producers engaged in developing active pharmaceutical ingredients (APIs), peptides, and other high-value compounds.

Application

• Pharmaceutical Intermediate: A critical starting material and chiral synthon for the synthesis of various active pharmaceutical ingredients (APIs) and prodrugs.
• Peptide Synthesis: Used in the preparation of peptides and peptidomimetics, where the pyroglutamic acid moiety can influence structure and biological activity.
• Agrochemical Production: Serves as a building block for developing novel herbicides, fungicides, and plant growth regulators.
• Cosmetic & Personal Care: Incorporated into formulations for its potential moisturizing (as a component of Natural Moisturizing Factor) and skin-conditioning properties.
• Biochemical Research: Utilized as a substrate or standard in enzymatic studies and metabolic pathway research, particularly related to the glutathione cycle.
• Flavor & Fragrance Industry: Acts as a precursor for certain flavor compounds and aroma chemicals.
• Asymmetric Synthesis: Employed as a chiral auxiliary or resolving agent in stereoselective chemical reactions.

Basic Information

Product Name	Dl-Pyroglutamic Acid
CAS No.	149-87-1
Molecular Formula	C5H7NO3
Molecular Weight	129.11 g/mol
Synonyms	5-Oxoproline; Pyrrolidonecarboxylic Acid; 2-Pyrrolidone-5-carboxylic Acid; Glutamic Acid 5-Lactam; DL-2-Pyrrolidone-5-carboxylic Acid; (±)-Pyroglutamic Acid; Pyroglutamic Acid (DL-); PCA; 5-Oxo-DL-proline
EINECS	205-757-1

Quality Control

Our Dl-Pyroglutamic Acid is manufactured under a strict quality management system. Each batch undergoes comprehensive analytical testing to ensure it meets high-purity standards suitable for pharmaceutical and fine chemical applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment and are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). Keep away from strong oxidizing agents and strong bases.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms
Assay (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition (Sulfated Ash)	≤ 0.1%
Heavy Metals (as Pb)	≤ 20 ppm
Specific Rotation	-0.10° to +0.10° (c=1 in H2O)
Related Substances (HPLC)	Total impurities ≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.