Description

5,6-Difluoro-1H-Indole-3-Carboxylic Acid is a high-purity fluorinated indole derivative, serving as a critical building block in advanced organic synthesis. Its value lies in the strategic placement of fluorine atoms, which can dramatically alter the physicochemical and metabolic properties of target molecules. This compound is essential for researchers and manufacturers in the pharmaceutical and agrochemical industries, particularly for developing new active ingredients and fine-tuning the bioactivity of lead compounds.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel drug candidates, especially in oncology, CNS disorders, and anti-inflammatory therapies.
• Agrochemical Research: Used in the synthesis of advanced herbicides, fungicides, and insecticides, where fluorine substitution enhances efficacy and environmental stability.
• Material Science Precursor: Employed in the creation of specialized organic electronic materials and functional dyes.
• Biochemical Probe Development: Serves as a core structure for designing fluorescent probes and enzyme inhibitors for biological research.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research institutions for bespoke chemical synthesis projects.

Basic Information

Product Name	5,6-Difluoro-1H-Indole-3-Carboxylic Acid
CAS No.	959238-71-2
Molecular Formula	C9H5F2NO2
Molecular Weight	197.14 g/mol
Synonyms	5,6-Difluoroindole-3-carboxylic acid; 1H-Indole-3-carboxylic acid, 5,6-difluoro-; 5,6-Difluoro-1H-indole-3-carboxylic acid; 3-Carboxy-5,6-difluoroindole; 5,6-Difluoro-3-indolecarboxylic acid
EINECS	Contact for details

Quality Control

Our 5,6-Difluoro-1H-Indole-3-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and NMR for structural confirmation, to ensure it meets the high standards required for research and commercial synthesis. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are available for every shipment upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.