Description

2-Butynoic Acid, 4-[(Trimethylsilyl)Oxy]-, Methyl Ester is a specialized silyl-protected acetylenic ester, serving as a valuable synthetic intermediate in advanced organic chemistry. Its core value lies in its dual functionality, where the trimethylsilyloxy group acts as a protecting group and the methyl ester provides a handle for further transformations. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries, particularly for constructing complex molecular architectures via controlled coupling and cyclization reactions. Its precise structure enables the synthesis of targeted bioactive molecules with high efficiency.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel drug candidates, especially those requiring acetylenic linkages or silicon-containing moieties.
• Agrochemical Synthesis: Used in the research and development of advanced pesticides and herbicides where specific acetylenic frameworks are required for biological activity.
• Material Science Research: Serves as a precursor for monomers or cross-linkers in the development of specialty polymers and advanced organic materials.
• Organic Synthesis Reagent: Employed in Sonogashira coupling, click chemistry, and other palladium-catalyzed cross-coupling reactions to introduce functionalized alkyne units.
• Chemical Biology Probes: Utilized in the creation of molecular probes and tags for studying biological processes due to its reactive alkyne group.

Basic Information

Product Name	2-Butynoic Acid, 4-[(Trimethylsilyl)Oxy]-, Methyl Ester
CAS No.	959024-96-5
Molecular Formula	C8H14O3Si
Molecular Weight	186.28 g/mol
Synonyms	Methyl 4-(trimethylsilyloxy)-2-butynoate; 4-(Trimethylsiloxy)-2-butynoic Acid Methyl Ester; 2-Butynoic acid, 4-(trimethylsiloxy)-, methyl ester; Methyl 4-(trimethylsilyloxy)but-2-ynoate; TMS-protected methyl butynoate; Methyl 4-(TMS-oxy)-2-butynoate
EINECS	Contact for details

Quality Control

Our production of 2-Butynoic Acid, 4-[(Trimethylsilyl)Oxy]-, Methyl Ester adheres to stringent internal quality standards to ensure batch-to-batch consistency and high purity for research and development applications. Each lot undergoes comprehensive analysis, including identity confirmation by spectroscopic methods and purity assessment by chromatographic techniques. Certificates of Analysis (COA) detailing specific results are available upon request to support your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed to exclude moisture. Keep away from heat, sparks, and open flame.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC/HPLC)	≥ 95.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.