Description

1-Bromo-3-(2,2-Difluoro-Ethoxy)-Benzene is a high-purity, functionalized aromatic building block of significant importance in advanced organic synthesis. Its core value lies in the strategic combination of a bromo substituent and a difluoroethoxy side chain, enabling precise molecular construction and the introduction of fluorine motifs. This compound is essential for researchers and process chemists in the pharmaceutical and agrochemical industries who require reliable, high-quality intermediates for the development of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for introducing fluorine-containing pharmacophores to modulate bioavailability and metabolic stability.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides where the difluoroethoxy group can enhance biological activity and environmental profile.
• Liquid Crystal & OLED Materials: Serves as a precursor in the development of fluorine-based electronic materials for displays and organic light-emitting diodes (OLEDs).
• Cross-Coupling Reactions: The bromo aryl group makes it an excellent substrate for Suzuki, Heck, and other palladium-catalyzed cross-coupling reactions to create complex biaryl structures.
• Chemical Research & Development: A versatile reagent for exploring new synthetic methodologies and creating specialized chemical libraries for screening.

Basic Information

Item	Details
Product Name	1-Bromo-3-(2,2-Difluoro-Ethoxy)-Benzene
CAS No.	958454-25-6
Molecular Formula	C8H7BrF2O
Molecular Weight	237.04 g/mol
Synonyms	3-Bromo-1-(2,2-difluoroethoxy)benzene; 1-Bromo-3-(2,2-difluoroethoxy)benzene; 3-(2,2-Difluoroethoxy)bromobenzene; m-Bromo-α,α-difluoroanisole; Benzene, 1-bromo-3-(2,2-difluoroethoxy)-; 958454-25-6
EINECS	Contact for details

Quality Control

Every batch of 1-Bromo-3-(2,2-Difluoro-Ethoxy)-Benzene is manufactured and tested under a strict quality management system. We ensure compliance with relevant industry standards for fine chemical intermediates. Comprehensive analytical testing, including HPLC, GC, and NMR, is performed to verify identity, purity, and impurity profiles. A detailed Certificate of Analysis (COA) is provided with each shipment to guarantee batch-to-batch consistency and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from heat, sparks, and open flame. The container should be kept tightly sealed to prevent moisture absorption.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.