Description

6-Oxabicyclo[3.1.0]Hexan-2-Ol,4-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]-,[1R-(1-α-,2-Bta-,4-α-,5-α-)]-(9Ci) CAS NO 135827-37-1 is a high-purity, stereochemically defined bicyclic ether-alcohol derivative, serving as a critical advanced pharmaceutical intermediate and chiral building block. Its complex, rigid molecular architecture makes it invaluable for constructing sophisticated active pharmaceutical ingredients (APIs) with precise three-dimensional control. This compound is primarily sought by research institutions and pharmaceutical manufacturers engaged in the development of novel therapeutics.

Application

• Pharmaceutical Intermediate: A key chiral synthon in the multi-step synthesis of complex drug candidates, particularly in antiviral, anticancer, and central nervous system (CNS) therapeutic areas.
• Chiral Building Block: Utilized in asymmetric synthesis to introduce stereogenic centers and fused ring systems into target molecules, enabling access to enantiomerically pure compounds.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization programs to explore new chemical space and improve drug-like properties.
• Process Chemistry Development: Serves as a starting material or intermediate in the scale-up and route scouting for GMP-compliant API manufacturing processes.
• Organic Synthesis Reagent: Used in academic and industrial laboratories for methodological development involving bicyclic frameworks and protected alcohol functionalities.

Basic Information

Product Name	6-Oxabicyclo[3.1.0]Hexan-2-Ol,4-[(Tetrahydro-2H-Pyran-2-Yl)Oxy]-,[1R-(1-α-,2-Bta-,4-α-,5-α-)]-(9Ci)
CAS No.	135827-37-1
Molecular Formula	C10H16O4
Molecular Weight	200.23 g/mol
Synonyms	(1R,2S,4R,5S)-4-[(Tetrahydro-2H-pyran-2-yl)oxy]-6-oxabicyclo[3.1.0]hexan-2-ol; (1R,2S,4R,5S)-4-(Tetrahydro-2H-pyran-2-yloxy)-6-oxabicyclo[3.1.0]hexan-2-ol; 6-Oxabicyclo[3.1.0]hexan-2-ol, 4-[(tetrahydro-2H-pyran-2-yl)oxy]-, (1R,2S,4R,5S)-; 135827-37-1; Bicyclic THP-protected diol; [1R-(1α,2β,4α,5α)]-4-[(Tetrahydro-2H-pyran-2-yl)oxy]-6-oxabicyclo[3.1.0]hexan-2-ol
EINECS	Contact for details

Quality Control

Our production of this advanced intermediate adheres to strict quality management systems, ensuring batch-to-batch consistency and high chemical purity. Each lot is fully characterized and undergoes rigorous analytical testing, including HPLC for purity and chiral analysis to confirm stereochemical integrity. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profile is provided with every shipment to support your quality and regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The compound may be hygroscopic (moisture-sensitive); keep the container tightly sealed under an inert atmosphere if specified.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Purity (HPLC)	≥ 98.0%
Chiral Purity	≥ 99.0% ee
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.