Description

5-Borono-4-Bromo-2-Chloropyridine is a high-value, multi-functional heterocyclic building block essential for modern synthetic chemistry. Its unique structure, featuring three distinct reactive sites (boronic acid, bromo, and chloro substituents), makes it a versatile precursor for constructing complex molecular architectures via cross-coupling reactions. This compound is primarily utilized by research chemists and process development scientists in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and advanced materials.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and insecticides, leveraging its halogen and boron functionalities for structural diversification.
• Material Science: Serves as a precursor for creating functionalized pyridine-based ligands, polymers, and organic electronic materials.
• Cross-Coupling Reactions: The boronic acid group enables Suzuki-Miyaura couplings, while the bromo and chloro groups are suitable for Buchwald-Hartwig amination, Ullmann coupling, and other palladium-catalyzed transformations.
• Chemical Biology & Proteomics: Employed in the design and synthesis of molecular probes, tags, and linkers for studying biological systems.
• Contract Research & Manufacturing (CRO/CMO): A critical raw material for custom synthesis and scale-up projects requiring precise functional group manipulation.

Basic Information

Product Name	5-Borono-4-Bromo-2-Chloropyridine
CAS No.	957062-85-0
Molecular Formula	C5H4BBrClNO2
Molecular Weight	236.26 g/mol
Synonyms	(4-Bromo-2-chloropyridin-5-yl)boronic acid; 5-Borono-4-bromo-2-chloropyridine; 4-Bromo-2-chloro-5-pyridineboronic acid; 2-Chloro-4-bromopyridine-5-boronic acid; B-(4-Bromo-2-chloro-5-pyridinyl)boronic acid; 957062-85-0; Boronic acid, B-(4-bromo-2-chloro-5-pyridinyl)-
EINECS	Contact for details

Quality Control

Our 5-Borono-4-Bromo-2-Chloropyridine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC, NMR, and elemental analysis, to ensure high purity and consistent performance for critical synthetic applications. Certificates of Analysis (COA) detailing batch-specific results are available upon request, providing full traceability and compliance documentation for your quality assurance protocols.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) to prevent moisture absorption and decomposition. Keep away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms
Identification (NMR)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.