Description

n-4-Methoxybenzyl 4-Boronobenzenesulfonamide is a specialized organoboron building block featuring a sulfonamide linker. This compound is valued for its dual functionality, combining a boronic acid derivative for cross-coupling reactions with a sulfonamide group that can serve as a directing or protecting group. It is primarily utilized by researchers and process chemists in the pharmaceutical and agrochemical industries for the synthesis of complex molecules, particularly in the development of protease inhibitors and other biologically active compounds.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of novel drug candidates, especially those targeting proteases like thrombin or factor Xa.
• Suzuki-Miyaura Cross-Coupling: Serves as a versatile boronic acid ester component for forming carbon-carbon bonds in medicinal chemistry and materials science.
• Chemical Biology Probes: Used in the development of activity-based probes (ABPs) for studying enzyme function and inhibition.
• Agrochemical Research: Employed in the discovery and optimization of new active ingredients for crop protection.
• Directed C-H Functionalization: The sulfonamide moiety can act as a directing group for selective metal-catalyzed C-H activation reactions.
• Library Synthesis: Enables the rapid generation of diverse compound libraries for high-throughput screening in drug discovery programs.

Basic Information

Product Name	n-4-Methoxybenzyl 4-Boronobenzenesulfonamide
CAS No.	957060-91-2
Molecular Formula	C14H16BNO4S
Molecular Weight	305.16 g/mol
Synonyms	4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide, N-(4-Methoxybenzyl)-; p-Methoxybenzyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenesulfonamide; 4-Borono-N-(4-methoxybenzyl)benzenesulfonamide; 4-(N-(4-Methoxybenzyl)sulfamoyl)phenylboronic acid, pinacol ester; 957060-91-2; B-(4-((4-Methoxybenzyl)sulfamoyl)phenyl)boronic acid pinacol ester
EINECS	Contact for details

Quality Control

Our n-4-Methoxybenzyl 4-Boronobenzenesulfonamide is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity for research and development applications. All materials are characterized by advanced analytical techniques including NMR, HPLC, and mass spectrometry. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your regulatory and quality assurance requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when possible to maintain stability and purity. Keep the container tightly sealed in a desiccator for long-term storage.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥95%
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.