Description

4-Bromo-1-(Difluoromethyl)-1H-Pyrazole is a high-purity, functionalized pyrazole derivative serving as a critical building block in advanced organic synthesis. This compound matters for its unique molecular architecture, which combines bromine and difluoromethyl substituents to enable precise structural modifications and introduce desirable physicochemical properties into target molecules. It is primarily needed by research chemists and process development scientists in the pharmaceutical and agrochemical industries for creating novel active ingredients and fine chemicals.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting kinase inhibitors and other small-molecule therapeutics.
• Agrochemical Synthesis: Used in the research and production of next-generation pesticides and herbicides, where the difluoromethyl group can enhance metabolic stability and bioavailability.
• Material Science Research: Serves as a precursor for synthesizing specialized ligands, functional polymers, or organic electronic materials due to its halogen and fluorine content.
• Chemical Biology Probes: Employed in the design and synthesis of molecular probes and tags for studying biological systems and enzyme mechanisms.
• Custom Synthesis & Contract Manufacturing: An essential starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) serving the life sciences sector.

Basic Information

Product Name	4-Bromo-1-(Difluoromethyl)-1H-Pyrazole
CAS No.	956477-67-1
Molecular Formula	C4H3BrF2N2
Molecular Weight	196.98 g/mol
Synonyms	4-Bromo-1-(difluoromethyl)-1H-pyrazole; 1H-Pyrazole, 4-bromo-1-(difluoromethyl)-; 4-Bromo-1-(difluoromethyl)pyrazole; 956477-67-1; 4-Bromo-1-difluoromethyl-1H-pyrazole; 4-Bromo-1-difluoromethylpyrazole
EINECS	Contact for details

Quality Control

Our 4-Bromo-1-(Difluoromethyl)-1H-Pyrazole is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with every shipment, detailing all critical quality attributes. Our commitment to quality supports applications in GMP and ISO-compliant environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (typically 15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.