Description

Benzene, 2-Ethynyl-1,4-Difluoro- is a specialized fluorinated aromatic building block featuring an ethynyl substituent. This compound is valued for its unique molecular architecture, which combines a difluorobenzene core with a terminal alkyne group, enabling advanced synthetic transformations. It is primarily sought by researchers and process chemists in the pharmaceutical and advanced materials sectors for applications in medicinal chemistry, agrochemical development, and the synthesis of novel polymers or liquid crystals.

Application

• Pharmaceutical Intermediate: A key synthon for constructing complex bioactive molecules, particularly in the development of fluorine-containing drug candidates.
• Agrochemical Synthesis: Used in the research and production of novel pesticides and herbicides, where the fluorine atoms can enhance biological activity and stability.
• Material Science Research: Serves as a monomer or precursor in the development of specialty polymers, liquid crystals, and organic electronic materials.
• Cross-Coupling Reactions: The ethynyl group makes it an excellent substrate for Sonogashira and other palladium-catalyzed cross-coupling reactions to create extended conjugated systems.
• Click Chemistry: Utilized in Huisgen cycloaddition (click) reactions to efficiently build complex molecular architectures for various R&D applications.
• Fluorine Chemistry Studies: Employed as a model compound in academic and industrial research to study the effects of fluorine substitution on aromatic systems.

Basic Information

Product Name	Benzene, 2-Ethynyl-1,4-Difluoro-
CAS No.	956386-38-2
Molecular Formula	C8H4F2
Molecular Weight	138.12 g/mol
Synonyms	2-Ethynyl-1,4-difluorobenzene; 1,4-Difluoro-2-ethynylbenzene; 2-Ethynyl-1,4-difluorobenzol; 1,4-Difluoro-2-ethynyl-benzene; 2-Ethynyl-p-difluorobenzene; 4-Fluoro-2-ethynyl-1-fluorobenzene; (2,5-Difluorophenyl)acetylene
EINECS	Contact for details

Quality Control

Our Benzene, 2-Ethynyl-1,4-Difluoro- is produced under strict quality management protocols. Each batch undergoes rigorous analytical testing to ensure high purity and consistency. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided and available upon request to support your quality assurance and regulatory needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at room temperature (15-25°C). Keep away from incompatible materials such as strong alkalis and fluorides. For long-term storage, consider storing under an inert atmosphere to maintain product integrity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Purity (GC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.