Description

(1S)-2,3-Dihydro-4,5-Dimethoxy-1H-Indene-1-Carboxylic Acid is a high-purity chiral intermediate of significant importance in advanced organic synthesis. This compound matters for its role as a key building block in the development of complex, biologically active molecules, offering precise stereochemical control. It is primarily needed by research institutions and pharmaceutical companies engaged in the synthesis of novel therapeutic agents and fine chemicals.

Application

• Pharmaceutical Intermediate: Serves as a critical chiral synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for central nervous system (CNS) targets.
• Asymmetric Synthesis: Used as a starting material or building block in catalytic asymmetric reactions to construct complex molecular architectures with high enantiomeric purity.
• Medicinal Chemistry Research: Employed in structure-activity relationship (SAR) studies and lead optimization for drug discovery programs.
• Fine Chemical Production: Integral to the multi-step synthesis of specialty chemicals, flavors, and fragrances requiring specific stereochemistry.
• Academic & Contract Research: Utilized in university laboratories and CROs (Contract Research Organizations) for methodological development and exploratory chemistry.
• Reference Standard: Can be supplied as a high-purity analytical standard for quality control and method validation in analytical laboratories.

Basic Information

Product Name	(1S)-2,3-Dihydro-4,5-Dimethoxy-1H-Indene-1-Carboxylic Acid
CAS No.	956101-03-4
Molecular Formula	C₁₂H₁₄O₄
Molecular Weight	222.24 g/mol
Synonyms	(1S)-4,5-Dimethoxyindane-1-carboxylic acid; (1S)-4,5-Dimethoxy-2,3-dihydro-1H-indene-1-carboxylic acid; (S)-4,5-Dimethoxyindane-1-carboxylic acid; (S)-4,5-Dimethoxy-2,3-dihydro-1H-indene-1-carboxylic acid; (1S)-1-Carboxy-4,5-dimethoxyindane; (S)-1-Carboxy-4,5-dimethoxyindane; (1S)-4,5-Dimethoxy-1-indanecarboxylic acid; (S)-4,5-Dimethoxy-1-indanecarboxylic acid
EINECS	Contact for details

Quality Control

Our (1S)-2,3-Dihydro-4,5-Dimethoxy-1H-Indene-1-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and standard purity assays, to ensure compliance with exacting customer specifications. A comprehensive Certificate of Analysis (COA) detailing identity, purity, and impurity profiles is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed after opening to minimize exposure to atmospheric moisture. For long-term storage, consider the use of desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Enantiomeric Excess (Chiral HPLC)	≥ 99.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals (as Pb)	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.