Description

2-Bromo-1-Difluoromethoxy-4-Trifluoromethyl-Benzene is a high-value, multi-fluorinated aromatic building block essential for advanced chemical synthesis. Its unique structure, featuring bromine, difluoromethoxy, and trifluoromethyl substituents, makes it a critical intermediate for introducing fluorine motifs, which are prized for their ability to modulate the lipophilicity, metabolic stability, and bioavailability of target molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: Key building block for synthesizing fluorinated drug candidates, particularly in oncology, CNS, and antiviral research.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides with enhanced efficacy and environmental profile.
• Material Science: Serves as a precursor for specialty polymers, liquid crystals, and organic electronic materials requiring fluorinated aromatic units.
• Chemical Research: Employed in cross-coupling reactions (e.g., Suzuki, Buchwald-Hartwig) and nucleophilic substitutions to construct complex molecular architectures.
• Fluorine Chemistry: A versatile substrate for further functionalization and exploration of structure-activity relationships (SAR) in medicinal chemistry.

Basic Information

Product Name	2-Bromo-1-Difluoromethoxy-4-Trifluoromethyl-Benzene
CAS No.	954236-03-4
Molecular Formula	C9H4BrF5O
Molecular Weight	303.03 g/mol
Synonyms	2-Bromo-α,α-difluoro-4-(trifluoromethyl)anisole; 1-Bromo-2-(difluoromethoxy)-5-(trifluoromethyl)benzene; Benzene, 2-bromo-1-(difluoromethoxy)-4-(trifluoromethyl)-; 2-Bromo-1-(difluoromethoxy)-4-(trifluoromethyl)benzene; 954236-03-4
EINECS	Contact for details

Quality Control

Every batch of 2-Bromo-1-Difluoromethoxy-4-Trifluoromethyl-Benzene is produced and tested under a strict quality management system. We provide comprehensive analytical data to ensure the material meets the precise requirements for advanced synthetic applications. A Certificate of Analysis (COA) detailing purity, identity, and impurity profiles by GC, HPLC, and NMR is supplied with each shipment. Our quality commitment supports compliance in cGMP and ISO 9001 environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong acids/organic solvents and fluorides/strong alkalis. The container should be kept tightly sealed in a dry environment to minimize exposure to moisture.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC/GC)	≥97.0% (Standard Grade)
Water Content (KF)	≤0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.