Description

1-Bromo-2-Difluoromethoxy-4-Fluoro-Benzene is a high-purity fluorinated aromatic building block of significant importance in advanced organic synthesis. Its unique structure, featuring bromine and difluoromethoxy substituents, makes it a versatile intermediate for constructing complex molecules. This compound is primarily sought after by research and development teams in the pharmaceutical and agrochemical industries for the creation of novel active ingredients.

Application

• Pharmaceutical Intermediate: A key building block in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders and metabolic diseases.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides, fungicides, and insecticides, where the difluoromethoxy group can enhance biological activity and metabolic stability.
• Material Science Precursor: Serves as a monomer or precursor for developing specialty polymers and liquid crystals with tailored electronic and optical properties.
• Cross-Coupling Reactions: The bromine atom acts as an excellent handle for palladium-catalyzed cross-coupling reactions (e.g., Suzuki, Heck, Sonogashira) to form new carbon-carbon bonds.
• Fluorine Chemistry Research: An essential reagent for studying the effects of fluorine and difluoromethoxy substitution on molecular conformation, lipophilicity, and bioavailability.
• Diagnostic Agent Development: Potential use in synthesizing radiolabeled compounds or contrast agents for positron emission tomography (PET) imaging.

Basic Information

Product Name	1-Bromo-2-Difluoromethoxy-4-Fluoro-Benzene
CAS No.	954235-83-7
Molecular Formula	C7H4BrF3O
Molecular Weight	241.01 g/mol
Synonyms	4-Fluoro-2-(difluoromethoxy)bromobenzene; 2-Bromo-1-difluoromethoxy-4-fluorobenzene; 1-Bromo-2-(difluoromethoxy)-4-fluorobenzene; Benzene, 1-bromo-2-(difluoromethoxy)-4-fluoro-; 954235-83-7; 4-Fluoro-2-difluoromethoxybromobenzene; 2-(Difluoromethoxy)-4-fluorobromobenzene
EINECS	Contact for details

Quality Control

Our 1-Bromo-2-Difluoromethoxy-4-Fluoro-Benzene is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. Certificates of Analysis (COA) detailing purity, impurity profiles, and physical characteristics are provided with each shipment. We adhere to cGMP principles where applicable to support our clients' regulatory filings.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from heat, sparks, and open flame. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.