Description

3-(4-Trifluoromethyl-Phenoxymethyl)-Azetidine is a specialized heterocyclic building block of significant interest in advanced organic synthesis. This compound matters for its role as a key intermediate in the development of novel active pharmaceutical ingredients (APIs) and agrochemicals, where its unique azetidine core and trifluoromethylphenoxy moiety impart valuable physicochemical properties. Pharmaceutical and agrochemical R&D teams need this high-purity intermediate to accelerate the discovery and process development of new therapeutic and crop protection agents.

Application

• Pharmaceutical Intermediate: A critical building block for the synthesis of novel drug candidates, particularly in medicinal chemistry programs targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the research and development of next-generation herbicides, fungicides, and insecticides, leveraging the bioactivity-enhancing trifluoromethyl group.
• Ligand and Catalyst Development: Serves as a precursor for creating novel chiral ligands and organocatalysts used in asymmetric synthesis.
• Material Science Research: Employed in the synthesis of advanced polymers and functional materials with specific optical or electronic properties.
• Chemical Biology Probes: Utilized to develop molecular probes for studying biological pathways and enzyme functions.

Basic Information

Product Name	3-(4-Trifluoromethyl-Phenoxymethyl)-Azetidine
CAS No.	954224-35-2
Molecular Formula	C11H12F3NO
Molecular Weight	231.22 g/mol
Synonyms	3-[(4-Trifluoromethylphenoxy)methyl]azetidine; 1-Azetidin-3-ylmethyl 4-trifluoromethyl phenyl ether; 4-[(Azetidin-3-yl)methoxy]benzotrifluoride; Azetidine, 3-[(4-(trifluoromethyl)phenoxy)methyl]-; 3-(4-Trifluoromethylphenoxymethyl)azetidine; 954224-35-2; 3-(p-Trifluoromethylphenoxymethyl)azetidine
EINECS	Contact for details

Quality Control

Our 3-(4-Trifluoromethyl-Phenoxymethyl)-Azetidine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and mass spectrometry, to ensure high chemical purity and identity confirmation. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specified parameters. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring traceability, consistency, and reliability for your critical R&D and scale-up processes.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled under a dry inert atmosphere (e.g., nitrogen or argon) to prevent degradation. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.