Description

Difluoro-(3-Iodo-Phenoxy)-Acetic Acid Ethyl Ester is a high-value fluorinated and iodinated aromatic building block designed for advanced synthetic chemistry. This compound is critical for introducing both fluorine and iodine functional groups into target molecules, enabling precise structural modifications and the development of novel materials. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for applications in medicinal chemistry, ligand synthesis, and the creation of specialty chemicals.

Application

• Pharmaceutical Intermediate: A key synthon in the research and development of new active pharmaceutical ingredients (APIs), particularly for candidates targeting CNS disorders and oncology.
• Agrochemical Synthesis: Used in the preparation of advanced herbicides and pesticides, where the difluoro and iodo substituents can enhance biological activity and environmental stability.
• Ligand and Catalyst Development: Serves as a precursor for sophisticated ligands in transition metal catalysis, facilitating challenging cross-coupling reactions.
• Material Science Research: Employed in the synthesis of fluorinated liquid crystals, organic semiconductors, and other specialty polymers with unique electronic properties.
• Chemical Biology Probes: Useful for synthesizing molecular probes and tags for imaging and diagnostic applications due to the presence of the iodine atom.
• Custom Synthesis and Contract Manufacturing: A vital starting material for custom synthesis projects requiring specific halogenated aromatic architectures.

Basic Information

Item	Details
Product Name	Difluoro-(3-Iodo-Phenoxy)-Acetic Acid Ethyl Ester
CAS No.	947533-66-6
Molecular Formula	C10H9F2IO3
Molecular Weight	342.08 g/mol
Synonyms	Ethyl 2,2-Difluoro-2-(3-iodophenoxy)acetate; 2-(3-Iodophenoxy)-2,2-difluoroacetic Acid Ethyl Ester; Ethyl Difluoro(3-iodophenoxy)acetate; 947533-66-6; Difluoro(3-iodophenoxy)acetic Acid Ethyl Ester; Acetic acid, 2,2-difluoro-2-(3-iodophenoxy)-, ethyl ester; Ethyl 2,2-difluoro-2-(3-iodo-phenoxy)acetate
EINECS	Contact for details

Quality Control

Every batch of Difluoro-(3-Iodo-Phenoxy)-Acetic Acid Ethyl Ester is produced and tested under a strict quality management system. We ensure high purity and consistency through advanced analytical techniques including HPLC, GC, and NMR spectroscopy. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with each shipment to support your R&D and scale-up activities.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at room temperature (15-25°C). Keep away from strong bases and reducing agents. For long-term storage, consider storing under an inert atmosphere to maintain optimal purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.