Description

5-Difluoromethoxyindole is a high-purity, advanced pharmaceutical intermediate characterized by its unique indole core substituted with a difluoromethoxy group. This compound matters as a critical building block in modern medicinal chemistry, enabling the synthesis of novel drug candidates with enhanced metabolic stability and bioavailability. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of targeted therapies, particularly in oncology and central nervous system (CNS) disorders.

Application

• Pharmaceutical Intermediate: A key synthon for the research and development of novel small-molecule drugs.
• API Synthesis: Used in the construction of complex active pharmaceutical ingredients (APIs) targeting various disease pathways.
• Medicinal Chemistry Research: Serves as a versatile scaffold for structure-activity relationship (SAR) studies and lead optimization.
• Preclinical Development: Employed in the synthesis of compounds for pharmacological and toxicological evaluation.
• Chemical Biology Probes: Utilized in the creation of specialized probes for studying biological mechanisms.
• Contract Manufacturing: Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis projects.

Basic Information

Product Name	5-Difluoromethoxyindole
CAS No.	947380-11-2
Molecular Formula	C9H7F2NO
Molecular Weight	183.16 g/mol
Synonyms	1H-Indole, 5-(difluoromethoxy)-; 5-(Difluoromethoxy)-1H-indole; 5-(Difluoromethoxy)indole; Indole, 5-(difluoromethoxy)-; 947380-11-2
EINECS	Contact for details

Quality Control

Our 5-Difluoromethoxyindole is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing to ensure identity, purity, and consistency, meeting the high standards required for pharmaceutical R&D. Certificates of Analysis (COA) with detailed chromatographic data (HPLC/GC) are provided for full traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (typically 15-25°C). The material is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.