Description

3-Chloro-2-(2-Fluorophenoxy)Aniline is a high-purity, specialized aromatic amine derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both chloro and fluoro substituents on a diphenyl ether backbone, makes it a valuable intermediate for creating complex molecules with tailored properties. This compound is primarily sought by research and development teams in the pharmaceutical and agrochemical industries for the synthesis of novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of novel drug candidates, particularly in central nervous system (CNS) and anti-inflammatory research.
• Agrochemical Synthesis: Building block for developing next-generation herbicides, fungicides, and insecticides with enhanced efficacy and selectivity.
• Material Science Research: Used in the development of specialty polymers, liquid crystals, and advanced organic electronic materials.
• Dye and Pigment Intermediate: Serves as a starting material for synthesizing complex, high-performance colorants and functional dyes.
• Cross-Coupling Reactions: Utilized in palladium-catalyzed reactions (e.g., Buchwald-Hartwig amination) to construct complex nitrogen-containing heterocycles.
• Custom Synthesis & Contract Manufacturing: Supplied to CDMOs and research organizations for bespoke chemical development projects.

Basic Information

Product Name	3-Chloro-2-(2-Fluorophenoxy)Aniline
CAS No.	946682-31-1
Molecular Formula	C12H9ClFNO
Molecular Weight	237.66 g/mol
Synonyms	3-Chloro-2-(2-fluorophenoxy)benzenamine; 2-Amino-6-chloro-2'-fluorodiphenyl ether; 1-Amino-2-chloro-3-(2-fluorophenoxy)benzene; Benzenamine, 3-chloro-2-(2-fluorophenoxy)-; 946682-31-1; 3-Chloro-2-(2-fluorophenoxy)phenylamine; 2-(2-Fluorophenoxy)-3-chloroaniline
EINECS	Contact for details

Quality Control

Our 3-Chloro-2-(2-Fluorophenoxy)Aniline is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant ICH guidelines for analytical procedures, and our quality commitment supports applications in regulated environments, including cGMP for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, sparks, and open flame. Due to its amine functionality and light-sensitive nature, prolonged exposure to light or air should be avoided to maintain product integrity.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.