Description

Pentafluorophenyl 1-Methylpiperidin-3-Carboxylate 90% is a high-purity fluorinated organic building block, specifically a pentafluorophenyl ester derivative of a substituted piperidine carboxylic acid. This compound is valued for its role as a key synthetic intermediate in advanced organic synthesis, particularly in the development of active pharmaceutical ingredients (APIs) and agrochemicals. It is primarily utilized by research institutions and industrial manufacturers in the pharmaceutical, agrochemical, and specialty chemical sectors for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of novel drug candidates, particularly those targeting the central nervous system (CNS) and other therapeutic areas.
• Agrochemical Research: Used in the development of advanced pesticides, herbicides, and fungicides where the fluorinated phenyl group enhances biological activity and stability.
• Chemical Biology & Proteomics: Serves as a reactive ester in activity-based protein profiling (ABPP) and for labeling biomolecules due to its high reactivity with amines.
• Material Science: Employed in the synthesis of specialty polymers and advanced materials where fluorinated components impart unique properties like chemical resistance and low surface energy.
• Cross-Coupling Reactions: Acts as an efficient substrate in palladium-catalyzed cross-coupling reactions for creating complex biaryl structures.
• Ligand & Catalyst Development: Used to synthesize novel ligands and organocatalysts for asymmetric synthesis.

Basic Information

Product Name	Pentafluorophenyl 1-Methylpiperidin-3-Carboxylate 90%
CAS No.	946409-23-0
Molecular Formula	C14H14F5NO2
Molecular Weight	323.26 g/mol
Synonyms	1-Methylpiperidine-3-carboxylic acid pentafluorophenyl ester; Pentafluorophenyl 1-methyl-3-piperidinecarboxylate; 3-(Pentafluorophenoxycarbonyl)-1-methylpiperidine; 1-Methyl-3-piperidinecarboxylic acid pentafluorophenyl ester; PFP-1-Methylnipecotate; Pentafluorophenyl ester of 1-methylnipecotic acid; 946409-23-0; PFP active ester
EINECS	Contact for details

Quality Control

Our Pentafluorophenyl 1-Methylpiperidin-3-Carboxylate 90% is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure identity, purity, and consistency. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee compliance with your research and production requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from strong bases and incompatible materials. The container must be kept tightly closed to prevent moisture absorption.

Specification

Item	Specification
Appearance	White to off-white solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥ 90.0%
Purity (HPLC, Area%)	≥ 95.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.