Description

(S)-n-Cbz-2-Methyl-Aziridine CAS NO 946088-68-2 is a high-purity, enantiomerically pure chiral aziridine derivative, serving as a critical building block in advanced organic synthesis. Its value lies in providing a protected, stereodefined three-membered nitrogen heterocycle that enables the efficient, stereocontrolled introduction of amine functionality into complex molecular architectures. This compound is essential for research chemists and process development scientists in the pharmaceutical and agrochemical industries, particularly for the synthesis of active pharmaceutical ingredients (APIs), chiral ligands, and novel bioactive compounds.

Application

• Pharmaceutical Intermediate: Key chiral synthon for the asymmetric synthesis of β-amino acids, amino alcohols, and complex amine-containing drug candidates.
• Agrochemical Synthesis: Building block for creating chiral herbicides, fungicides, and plant growth regulators with enhanced efficacy.
• Catalyst & Ligand Development: Precursor for synthesizing novel chiral catalysts and ligands used in asymmetric hydrogenation and other enantioselective transformations.
• Peptidomimetics & PROTACs: Used in the construction of peptidomimetic scaffolds and Proteolysis-Targeting Chimeras (PROTACs) for drug discovery.
• Material Science: Monomer or precursor for specialty polymers and advanced materials requiring specific chiral centers.
• Academic & Process R&D: Valuable reagent for methodological development in organic chemistry and scale-up process optimization.

Basic Information

Product Name	(S)-n-Cbz-2-Methyl-Aziridine
CAS No.	946088-68-2
Molecular Formula	C12H15NO2
Molecular Weight	205.25 g/mol
Synonyms	(S)-1-[(Benzyloxy)carbonyl]-2-methylaziridine; (S)-2-Methyl-1-[(phenylmethoxy)carbonyl]aziridine; (S)-N-Carbobenzoxy-2-methylaziridine; (S)-Cbz-2-Methylaziridine; (2S)-2-Methyl-1-{[(benzyloxy)carbonyl]amino}aziridine; (S)-1-(Benzyloxycarbonyl)-2-methylaziridine; Aziridine-1-carboxylic acid, 2-methyl-, phenylmethyl ester, (2S)-
EINECS	Contact for details

Quality Control

Our (S)-n-Cbz-2-Methyl-Aziridine is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral HPLC for enantiomeric excess (ee) and purity assessment, to ensure it meets the high standards required for research and process chemistry. Certificates of Analysis (COA) detailing identity, purity, chiral purity, and impurity profiles are provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C or as indicated on the label. This compound is hygroscopic (moisture-sensitive) and should be handled under an inert atmosphere (e.g., nitrogen or argon) when prolonged exposure is anticipated to maintain stability and purity.

Specification

Item	Specification
Appearance	Colorless to pale yellow liquid or low-melting solid
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Chiral Purity (Chiral HPLC)	≥ 98.0% ee
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.