Description

5-Bromo-2-(trifluoromethyl)isonicotinaldehyde is a high-value, multi-functional heterocyclic building block. This compound is critical for introducing both bromo and trifluoromethyl substituents onto a pyridine core, enabling precise molecular tuning in advanced synthesis. It is primarily sought after by research and development chemists in the pharmaceutical and agrochemical industries for the creation of novel active ingredients and complex intermediates.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of potential drug candidates, particularly kinase inhibitors and other small molecule therapeutics.
• Agrochemical Research: Used in developing new herbicides, fungicides, and insecticides where the trifluoromethyl group enhances biological activity and metabolic stability.
• Material Science: Serves as a building block for creating functionalized ligands, organic semiconductors, and specialty polymers.
• Cross-Coupling Reactions: The bromine atom makes it an excellent substrate for palladium-catalyzed reactions like Suzuki, Sonogashira, and Buchwald-Hartwig couplings.
• Aldehyde Functionalization: The aldehyde group allows for further derivatization through condensation, reduction, or nucleophilic addition reactions.
• Fluorine Chemistry: Essential for studying structure-activity relationships (SAR) in medicinal chemistry due to the influence of the trifluoromethyl group.

Basic Information

Product Name	5-Bromo-2-(trifluoromethyl)isonicotinaldehyde
CAS No.	944904-60-3
Molecular Formula	C7H3BrF3NO
Molecular Weight	253.01 g/mol
Synonyms	5-Bromo-2-(trifluoromethyl)pyridine-4-carbaldehyde; 4-Bromo-6-(trifluoromethyl)pyridine-3-carboxaldehyde; 5-Bromo-2-trifluoromethylisonicotinaldehyde; 5-Bromo-2-(trifluoromethyl)-4-pyridinecarboxaldehyde; 5-Bromo-2-(trifluoromethyl)pyridine-4-carboxaldehyde; 4-Pyridinecarboxaldehyde, 5-bromo-2-(trifluoromethyl)-; 944904-60-3
EINECS	Contact for details

Quality Control

Our 5-Bromo-2-(trifluoromethyl)isonicotinaldehyde is manufactured under strict quality management systems. Every batch undergoes comprehensive analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. A detailed Certificate of Analysis (COA) is provided with each shipment, confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at a controlled room temperature (15-25°C). This material is easily oxidized and should be handled under an inert atmosphere for long-term storage. Keep away from heat and incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 97.0%
Melting Point	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.