Description

3-Chloro-5-(Trifluoromethyl)Benzaldehyde is a versatile aromatic aldehyde building block characterized by its chloro and trifluoromethyl substituents, which impart unique electronic and steric properties. This compound is crucial for the synthesis of advanced pharmaceutical intermediates and agrochemicals, where its structure enables the fine-tuning of biological activity and physicochemical properties. It is primarily sought after by research and development chemists in the pharmaceutical, agrochemical, and specialty chemical industries for creating novel active ingredients and functional materials.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group enhances lipophilicity and metabolic stability.
• Ligand and Catalyst Development: Serves as a starting material for synthesizing specialized ligands used in asymmetric catalysis and transition metal complexes.
• Material Science: Employed in the creation of organic electronic materials, liquid crystals, and advanced polymers due to its electron-withdrawing groups.
• Chemical Research: A valuable reagent in academic and industrial R&D for exploring novel organic reactions and constructing complex molecular architectures.
• Dye and Pigment Intermediate: Functions as a building block for synthesizing specialized dyes and pigments with specific color fastness and stability properties.

Basic Information

Product Name	3-Chloro-5-(Trifluoromethyl)Benzaldehyde
CAS No.	477535-43-6
Molecular Formula	C8H4ClF3O
Molecular Weight	208.56 g/mol
Synonyms	3-Chloro-5-(trifluoromethyl)benzaldehyde; 5-Chloro-3-(trifluoromethyl)benzaldehyde; 3-Chloro-alpha,alpha,α-trifluoro-m-tolualdehyde; m-Chloro-alpha,alpha,α-trifluorotoluene-5-carboxaldehyde; Benzaldehyde, 3-chloro-5-(trifluoromethyl)-; 3-Chloro-5-trifluoromethylbenzaldehyde; 3-Chloro-5-(trifluoromethyl)benzenecarboxaldehyde
EINECS	Contact for details

Quality Control

Our 3-Chloro-5-(Trifluoromethyl)Benzaldehyde is manufactured under a strict quality management system. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high purity and consistent quality suitable for sensitive synthetic applications. Certificates of Analysis (COA) detailing purity, identity, and impurity profiles are provided with every shipment. We adhere to cGMP principles where applicable to support our clients' regulatory requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep away from incompatible materials such as strong bases and fluorides. The container must be kept tightly sealed to prevent moisture absorption and contamination.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Single Unknown Impurity (HPLC)	≤ 0.5%
Total Impurities (HPLC)	≤ 2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.